Stereochemistry and reactivity of the HPA-imine Mannich intermediate

DOI: 10.1016/j.tetlet.2017.08.070

Source and publish data:

Tetrahedron Letters p. 3879 - 3883 (2017)

Update date:2022-08-05

Topics: Reactivity Stereochemistry

Authors:

Polyak, Daniel

Phung, Ngan

Liu, Jian

Barrows, Robert

Emge, Thomas J.

Knapp, Spencer

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Article abstract of DOI:10.1016/j.tetlet.2017.08.070

Homophthalic anhydride (HPA) typically reacts rapidly with benzalimines to afford the formal [4+2] adduct, a 1,2,3,4-tetrahydroisoquinolin-1-one-4-carboxylic acid. The stereochemical outcome of this reaction is consistent with an open transition state com

Full text of DOI:10.1016/j.tetlet.2017.08.070

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