106718-56-3Relevant articles and documents
Expeditious synthesis of ivacaftor
He, Yang,Xu, Qien,Ma, Wenpeng,Zhang, Jian,Sun, Hongbing,Shen, Jingshan
, p. 1035 - 1040 (2014)
An expeditious synthesis for Ivacaftor featuring modified Leimgruber-Batcho procedure was described. The overall yield is 39% over six steps from commercially available 2-nitrobenzoyl chloride.
2-arylquinolines and process for producing the same
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, (2008/06/13)
2-Arylquinolines represented by formula (1): STR1 wherein R 1, R 3 to R 9 each represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy or --C m F 2m+1 ; R 2 represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl,
2,2-Disubstituted-1,2-dihydro-3H-indol-3-ones by Base- and Thermal-induced Cyclisations of o-Azidophenyl s-Alkyl Ketones and o-Azidobenzoyl Esters
Azadi-Ardakani, Manouchehr,Alkhader, Mohamed A.,Lippiatt, John H.,Patel, Dalpat I.,Smalley, Robert K.,Higson, Susan
, p. 1107 - 1112 (2007/10/02)
o-Azidophenyl s-alkyl ketones in ethanolic potassium hydroxide at room temperature undergo loss of nitrogen and cyclisation to 2,2-dialkyl-1,2-dihydro-3H-indol-3-ones in high yield.Kinetic data (E(act.) 62.4 and 71.6 kJ mol-1, respectively) obtained for the o-azidophenylisopropyl and o-azidophenylcyclohexyl ketones support an assisted nitrogen loss from the azide via the enolate ion, rather than a nitrene reaction. 1,2-Dihydro-3H-indol-3-ones, along with in some cases 2,1-benzisoxazoles, have been obtained by the thermolysis and spray vacuum pyrolysis of other o-azidophenyl alkyl ketones, diethyl o-azidobenzoyl malonate, and ethyl o- azidobenzoyl(phenyl)acetate.
