1067239-08-0

Basic information

• Product Name: 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid
• Synonyms: 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid;1-Boc-3-hydroxypyrrolidine-3-carboxylic acid;3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid
• CAS NO: 1067239-08-0
• Molecular Formula: C10H17NO5
• Molecular Weight: 231.24568
• EINECS: -0
• Mol File: 1067239-08-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 384.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.324±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.74±0.20(Predicted)
• CAS DataBase Reference: 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid(1067239-08-0)
• EPA Substance Registry System: 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid(1067239-08-0)

Safety Data

• Hazardous Substances Data: 1067239-08-0(Hazardous Substances Data)

Usage

General Description

1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid is a chemical compound with a molecular formula C11H19NO5. It is a derivative of pyrrolidine, an organic compound commonly used in the synthesis of pharmaceuticals and agrochemicals. The tert-butoxycarbonyl (Boc) group is a protecting group for amines, which is commonly used in organic synthesis to temporary mask the amine group and to prevent unwanted reactions. The hydroxyl group and the carboxylic acid group present in this compound make it a potential intermediate in the production of pharmaceuticals and other organic compounds. Overall, 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid is an important compound in organic synthesis and has potential applications in the pharmaceutical and chemical industries.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 75315-60-5 3-hydroxypyrrolidine-3-carboxylic acid 

Relevant articles and documents

Preparation method of oxazaspiro compound

The invention discloses a preparation method of an oxazaspiro compound, which comprises the following steps: by using substituted saturated azaspiro alkane (compound II) as a raw material, performinghydrolyzing under an alkaline condition to obtain a compound III; carrying out condensation reaction on the compound III and a salt of a compound IV (halogenated alkylamine)/compound IV to generate acompound V; and finally, cyclizing the compound V under an alkaline condition to obtain the lactam oxazaspiro compound I.

ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (Formula (I)), including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.