106745-25-9

Upstream product

• 75-64-9 tert-butylamine 
• 529-20-4 2-methylphenyl aldehyde 
• 615-37-2 ortho-methylphenyl iodide 
• 119072-55-8 tert-butylisonitrile 
• 112093-21-7 2-methyl-N-(2-methylbenzyl)propan-2-amine 

Downstream Products

• 96964-45-3 2-(8-phenyloctyl) benzaldehyde 
• 880175-80-4 1-({(2R,3S)-3-[2-(8-phenyloctyl)phenyl]oxiranyl}carbonyl)-pyrrole 
• 880175-79-1 1-({(2R,3S)-3-[2-(8-phenyloctyl)phenyl]oxiranyl}carbonyl)-2,5-dihydropyrrole 
• 880175-81-5 3-{[(1R,2S)-2-hydroxy-3-oxo-1-[2-(8-phenyloctyl)phenyl]-3-(pyrrolyl)propyl]sulfanyl}propionic acid methyl ester 
• 107023-41-6 pobilukast 
• 112093-21-7 2-methyl-N-(2-methylbenzyl)propan-2-amine 
• 1352803-24-7 3,3'-diphenyl-4,4'-bisisoquinoline 
• 37993-76-3 3-phenylisoquinoline 
• 51089-62-4 4-Methyl-3-phenylisoquinoline 
• 1352803-23-6 N-(tert-butyl)-3-phenylisoquinolin-1-amine 
• 499181-93-0 4-chloro-3-phenylisoquinoline 
• 1417212-32-8 C₁₉H₂₁LiN₂ 
• 1431660-56-8 2,2,2-trichloro-N-(2-methylbenzyl)acetamide 
• 1450995-41-1 C₁₇H₁₂F₃NO₂ 

Relevant academic research and scientific papers

Convenient fabrication of carbon doped WO3?x ultrathin nanosheets for photocatalytic aerobic oxidation of amines

It is an important chemical transformation for oxidation of amines to imines, on account of very important versatile applications of imines in organic synthesis. Here, we develop a convenient way to synthesize carbon doped WO3?x ultrathin nanos

Diastereodivergent [3 + 2] Annulation of Aromatic Aldimines with Alkenes via C-H Activation by Half-Sandwich Rare-Earth Catalysts

Stereodivergent catalysis is of great importance, as it can allow efficient access to all possible stereoisomers of a given product with multiple stereocenters from the same set of starting materials. We report herein the first diastereodivergent [3 + 2]

2D sp2 Carbon-Conjugated Porphyrin Covalent Organic Framework for Cooperative Photocatalysis with TEMPO

2D covalent organic frameworks (COFs) are receiving ongoing attention in semiconductor photocatalysis. Herein, we present a photocatalytic selective chemical transformation by combining sp2 carbon-conjugated porphyrin-based covalent organic framework (Por-sp2c-COF) photocatalysis with TEMPO catalysis illuminated by 623 nm red light-emitting diodes (LEDs). Highly selective conversion of amines into imines was swiftly afforded in minutes. Specifically, the π-conjugation of porphyrin linker leads to extensive absorption of red light; the sp2 ?C=C? double bonds linkage ensures the stability of Por-sp2c-COF under high concentrations of amine. Most importantly, we found that crystalline framework of Por-sp2c-COF is pivotal for cooperative photocatalysis with (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO). This work foreshadows that the outstanding hallmarks of COFs, particularly crystallinity, could be exploited to address energy and environmental challenges by cooperative photocatalysis.

Transient imine as a directing group for the metal-free o-C-H borylation of benzaldehydes

Organoboron reagents are important synthetic intermediates and have wide applications in synthetic organic chemistry. The selective borylation strategies that are currently in use largely rely on the use of transition-metal catalysts. Hence, identifying much milder conditions for transition-metal-free borylation would be highly desirable. We herein present a unified strategy for the selective C-H borylation of electron-deficient benzaldehyde derivatives using a simple metal-free approach, utilizing an imine transient directing group. The strategy covers a wide spectrum of reactions and (i) even highly sterically hindered C-H bonds can be borylated smoothly, (ii) despite the presence of other potential directing groups, the reaction selectively occurs at the o-C-H bond of the benzaldehyde moiety, and (iii) natural products appended to benzaldehyde derivatives can also give the appropriate borylated products. Moreover, the efficacy of the protocol was confirmed by the fact that the reaction proceeds even in the presence of a series of external impurities.

Formal Ir-Catalyzed Ligand-Enabled Ortho and Meta Borylation of Aromatic Aldehydes via in Situ-Generated Imines

The ligand-enabled development of ortho and meta C-H borylation of aromatic aldehydes is reported. It was envisaged that while ortho borylation could be achieved using tert-butylamine as the traceless protecting/directing group, meta borylation proceeds via an electrostatic interaction and a secondary interaction between the ligand of the catalyst and the substrate. These ligand-substrate electrostatic interactions and secondary B-N interactions provide an unprecedented controlling factor for meta-selective C-H activation/borylation.

Palladium-catalyzed synthesis of aldehydes from aryl halides and tert-butyl isocyanide using formate salts as hydride donors

An efficient one-pot palladium-catalyzed hydroformylation of aryl halides to produce aromatic aldehydes has been achieved, employing tert-butyl isocyanide as a C1 resource and formate salt as a hydride donor without any additional bases. Characterized by its mild reaction conditions, easy operation and lower toxicity, this reaction can tolerate a wide array of functional groups with moderate to excellent yields.

Regiospecific synthesis of novel cyclic nitrostyrenes and 3-substituted 2-nitronaphthalenes

A two-step, practical, regiospecific, and readily scalable benzannulation protocol for the preparation of novel 3-alkyl- and 3-aryl-substituted 2-nitronaphthalenes is disclosed. Addition of a β-nitrostyrene or nitroalkene to a solution of freshly prepared lithiated o-tolualdehyde tert-butyl imine first leads to the formation of a nitronate, via rapid 1,4-addition, then an intramolecular aza-Henry reaction takes place to afford a six-membered carbocycle. Subsequent treatment of the reaction mixture with aqueous acid affords novel substituted cyclic nitrostyrenes that can be conveniently aromatized via a one-pot radical-induced bromination and elimination sequence to furnish the corresponding 3-alkyl- or 3-aryl-2-nitronaphthalenes in excellent yields. The straightforward syntheses of 2-aminonaphthalenes, substituted BINAMs, 2-naphthols as well as tricyclic fused 1,2,3-triazoles are also described. Georg Thieme Verlag Stuttgart. New York.

METHODS FOR PREPARING ISOQUINOLINES

Provided herein are novel synthetic methods of making isoquinolines comprising coupling a metalated N-(2-methylbenzylidene)amine with a nitrile, followed by cyclization, to provide a substituted isoquinoline compound. This new methodology for preparing is

Intramolecular C(sp3)-N coupling by oxidation of benzylic C,N-dianions

What a couple! An intramolecular, C(sp3)-N coupling to afford azacycles is reported. This reaction proceeds through the oxidation of benzylic C,N-dianions with iodine and builds on an earlier discovery during the synthesis of the natural produc

Dearomative radical spirocyclization from N-ce: Raghubenzyltrichloroacetamides revisited using a copper(I)-mediated atom transfer reaction leading to 2-azaspiro[4.5]decanes

An atom transfer radical dearomatizing spirocyclization from N-benzyltrichloroacetamides using CuCl regioselectively leads to 2-azaspiro[4.5]decadienes, in which the labile allylic chlorine atom is easily replaced by a hydroxyl group in aqueous medium or by quenching with methanol or allylamine. After oxidation of the target compound, the N-tert-butyl group can be removed from the resulting spirocyclohexanedienone.