112093-21-7Relevant academic research and scientific papers
Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production
Cameron, Michael D.,Griffin, Patrick R.,Kamenecka, Theodore M.,Lin, Hua,Lin, Li,Novick, Scott J.,Puigserver, Pere,Ruiz, Claudia,Sharabi, Kfir,Zhu, Di
supporting information, p. 980 - 990 (2021/02/01)
Despite a myriad of available pharmacotherapies for the treatment of type 2 diabetes (T2D), challenges still exist in achieving glycemic control. Several novel glucose-lowering strategies are currently under clinical investigation, highlighting the need f
Intramolecular C(sp3)-N coupling by oxidation of benzylic C,N-dianions
Jeffrey, Jenna L.,Bartlett, Emily S.,Sarpong, Richmond
supporting information, p. 2194 - 2197 (2013/03/28)
What a couple! An intramolecular, C(sp3)-N coupling to afford azacycles is reported. This reaction proceeds through the oxidation of benzylic C,N-dianions with iodine and builds on an earlier discovery during the synthesis of the natural produc
Dearomative radical spirocyclization from N-ce: Raghubenzyltrichloroacetamides revisited using a copper(I)-mediated atom transfer reaction leading to 2-azaspiro[4.5]decanes
Diaba, Fa?za,Montiel, Juan A.,Martínez-Laporta, Agustín,Bonjoch, Josep
, p. 2619 - 2622 (2013/06/05)
An atom transfer radical dearomatizing spirocyclization from N-benzyltrichloroacetamides using CuCl regioselectively leads to 2-azaspiro[4.5]decadienes, in which the labile allylic chlorine atom is easily replaced by a hydroxyl group in aqueous medium or by quenching with methanol or allylamine. After oxidation of the target compound, the N-tert-butyl group can be removed from the resulting spirocyclohexanedienone.
Kinetic control of the direction of inclusion of nitroxide radicals into cyclodextrins
Franchi, Paola,Casati, Costanza,Mezzina, Elisabetta,Lucarini, Marco
experimental part, p. 6396 - 6401 (2011/10/10)
N-benzyl-tert-butyl nitroxide derivatives substituted at the aromatic ring form host-guest inclusion complexes with β-and γ-cyclodextrin. They were employed as probes to assess substituent effects on the geometry of the complex and on the kinetics of this
