1067883-56-0

Basic information

• Product Name: 1H-Indole, 2-[2-(diphenylphosphino)phenyl]-1-methyl-
• CAS NO: 1067883-56-0
• Molecular Formula: C27H22NP
• Molecular Weight: 391.452
• Mol File: 1067883-56-0.mol

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 2-[2-(diphenylphosphino)phenyl]-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2-[2-(diphenylphosphino)phenyl]-1-methyl-(1067883-56-0)
• EPA Substance Registry System: 1H-Indole, 2-[2-(diphenylphosphino)phenyl]-1-methyl-(1067883-56-0)

Safety Data

• Hazardous Substances Data: 1067883-56-0(Hazardous Substances Data)

Usage

Chemical structure

An indole ring with a methyl group (CH3) and a phosphino-phenyl group (Ph2PPh) attached to it.

Usage as a ligand

Commonly used in coordination chemistry, particularly in the synthesis of transition metal complexes.

Application in catalysis

Utilized in the development of catalysts for various organic reactions, such as cross-coupling and hydrogenation reactions.

Pharmaceutical industry relevance

Has potential applications in the synthesis of bioactive molecules.

Versatility in organic synthesis

Serves as a valuable building block in organic synthesis with important applications across various fields of chemistry.

Upstream product

• 88207-45-8 2-(2'-bromophenyl)-1H-indole 
• 1011736-72-3 N-[1-(2-Bromo-phenyl)-eth-(Z)-ylidene]-N'-phenyl-hydrazine 
• 2142-69-0 2-bromophenyl methyl ketone 
• 1067883-80-0 N-methyl-2-(2'-bromophenyl)-1H-indole 
• 1079-66-9 chloro-diphenylphosphine 

Relevant articles and documents

Direct Copper-Catalyzed C-3 Arylation of Diphenylphosphine Oxide Indoles

We have developed a simple and effective method for the C-3 arylation of phosphorus-containing indole compounds in the presence of CuI under mild conditions. This reaction provides a reliable method for the modification of ligands.

Suzuki-Miyaura coupling of aryl tosylates catalyzed by an array of indolyl phosphine-palladium catalysts

A family of indolyl phosphine ligands was applied to Suzuki-Miyaura cross-coupling of aryl tosylates. Catalyst loading can be reduced to 0.2 mol % for coupling of nonactivated aryl tosylate. A challenging example for room temperature coupling is realized. The scope of this highly active Pd/L2 system can be extended to other boron nucleophiles, including trifluoroborate salts and boronate esters. The ligand structural comparisons toward the reactivity in tosylate couplings are also described.

A general palladium-catalyzed Suzuki-Miyaura coupling of aryl mesylates

(Chemical Equation Presented) Catalyze this! The first palladium-catalyzed Suzuki-Miyaura coupling of unactivated aryl mesylates is reported, with not only arylboronic acids, but also other organoboron nucleophiles (see picture; Z=B(OH)2, BF3K, BPin). The reaction conditions are compatible with various common functional groups (R1=alkyl, OMe, CHO, CO, CN, CO2R′, heteroaryl).