1067887-43-7

Basic information

• Product Name: phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol
• Synonyms: phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol
• CAS NO: 1067887-43-7
• Molecular Weight: 224.262
• Mol File: 1067887-43-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol(1067887-43-7)
• EPA Substance Registry System: phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol(1067887-43-7)

Safety Data

• Hazardous Substances Data: 1067887-43-7(Hazardous Substances Data)

Upstream product

• 344327-11-3 1H-pyrrolo[2,3-b]pyridine-4-carbonitrile 
• 100-52-7 benzaldehyde 
• 348640-06-2 4-bromo-7-azaindole 

Relevant articles and documents

Photo-induced reductive cross-coupling of aldehydes, ketones and imines with electron-deficient arenes to construct aryl substituted alcohols and amines

Umpolung reactions of C=X bonds (X = O, N) are valuable ways of constructing new C–C bonds, which are sometimes difficult to be constructed using traditional synthetic pathways. Classical polarity inversion of C=X bonds (X = O, N) usually requires air or moisture-sensitive and strong reducing agents, which limit the feasibility of substrate scope. Herein we describe a photo-induced reductive cross-coupling reaction of aldehydes, ketones and imines with electron-deficient arenes (aromatic nitriles) using fac-Ir(ppy)3 as a photocatalyst and diisopropylethylamine (DIPEA) as a terminal reductant under visible light irradiation. Mild conditions and high yields mean that this new polarity inversion strategy can be used with aryl-substituted alcohols and amines. Spectroscopic studies and control experiments have demonstrated the oxidative quenching of Ir(ppy)3* by electron-deficient arenes involved in the key step for the C–C bond formation.