87087-33-0

Basic information

• Product Name: 2-Propenoic acid, 3-(3-phenoxyphenyl)-, methyl ester
• CAS NO: 87087-33-0
• Molecular Formula: C16H14O3
• Molecular Weight: 254.285
• Mol File: 87087-33-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(3-phenoxyphenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(3-phenoxyphenyl)-, methyl ester(87087-33-0)
• EPA Substance Registry System: 2-Propenoic acid, 3-(3-phenoxyphenyl)-, methyl ester(87087-33-0)

Safety Data

• Hazardous Substances Data: 87087-33-0(Hazardous Substances Data)

Upstream product

• 1779-58-4 (methyloxycarbonylmethyl)triphenylphosphonium bromide 
• 39515-51-0 3-Phenoxybenzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 67-56-1 methanol 
• 77124-20-0 (E)-3-(3-phenoxyphenyl)acrylic acid 
• 141-82-2 malonic acid 

Downstream Products

• 106797-69-7 3-(3-phenoxyphenyl)propan-1-ol 
• 112270-89-0 N-hydroxy-3-(3-phenoxyphenyl)-2-propenamine hydrochloride 
• 112270-90-3 N-Acetoxy-N-[(E)-3-(3-phenoxy-phenyl)-allyl]-acetamide 
• 112270-88-9 N-[(E)-3-(3-Phenoxy-phenyl)-allyl]-O-(tetrahydro-pyran-2-yl)-hydroxylamine 
• 106328-57-8 N-(3-phenoxycinnamyl)acetohydroxamic acid 
• 115488-27-2 methyl 3-(3-phenoxyphenyl)propanoate 
• 112270-87-8 E-3-(3-phenoxyphenyl)-1-bromoprop-2-ene 

Relevant articles and documents

Nickel-Catalyzed Alkyl-Alkyl Cross-Electrophile Coupling Reaction of 1,3-Dimesylates for the Synthesis of Alkylcyclopropanes

Cross-electrophile coupling reactions of two Csp3-X bonds remain challenging. Herein we report an intramolecular nickel-catalyzed cross-electrophile coupling reaction of 1,3-diol derivatives. Notably, this transformation is utilized to synthesize a range of mono- and 1,2-disubstituted alkylcyclopropanes, including those derived from terpenes, steroids, and aldol products. Additionally, enantioenriched cyclopropanes are synthesized from the products of proline-catalyzed and Evans aldol reactions. A procedure for direct transformation of 1,3-diols to cyclopropanes is also described. Calculations and experimental data are consistent with a nickel-catalyzed mechanism that begins with stereoablative oxidative addition at the secondary center.

PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS

The present invention relates to novel compounds which are highly selective inhibitors of diacylglycerol lipase α and β. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by increased 2-arachidonoylglycerol levels. Diacylglycerol lipase-α (alternative name: Sn1-specific diacylglycerol hydrolase a; DAGL-α) and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion. The inventive ompounds are in particular suitable for the treatment of neurodegenerative diseases, inflammatory diseases, drug abuse and impaired energy balance, such as obesity.

Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 2-Oxetanones with a meta-substituent on the benzene ring in the side chain

Isosteric side chain analogs of 3a were synthesized and tested for inhibitory activities towards 3-hydroxy-3-methylglutaryl coenzyme A (HMG- CoA) synthase and upon cholesterol production in Hep G2 cells and in mouse liver. It became clear that the lipophi