106799-15-9

Upstream product

• 114861-21-1 2,3-dideoxy-3,5-O-(1-methylethylidene)-1-O-(phenylmethyl)-D-erythro-hexitol 
• 256659-01-5 (+)-(2S,4S)-1-acetoxy-6-benzyloxy-syn-2,4-(isopropylidenedioxy)-1-(p-tolylthio)hexane 
• 77-76-9 2,2-dimethoxy-propane 
• 171523-69-6 (+)-<3(R),5(S),S(R)>-Methyl syn-3,5-(isopropylidenedioxy)-6-(p-tolylsulfinyl)hexanoate 
• 114861-31-3 2,4-dideoxy-6-O-(phenylmethyl)-D-erythro-hexitol 1-(2,2-dimethyl-propanoate) 
• 114861-32-4 2,4-dideoxy-3,5-O-(1-methylethylidene)-6-O-(phenylmethyl)-D-erythro-hexitol 1-(2,2-dimethylpropanoate) 
• 106862-35-5 (2S,4R)-7-<<(1,1-dimethylethyl)diphenylsilyl>oxy>5-hexene-2,4-diol 
• 114861-19-7 <4S-(4β,6β)>-6-ethenyl-4-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,2-dimethyl-1,3-dioxane 
• 114861-20-0 2,3-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>3,5-O-(1-methylethylidene)-D-erythro-hexitol 
• 106799-14-8 2,3-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-1-O-(phenylmethyl)-D-erythro-hexitol 
• 114861-34-6 2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate) 
• 532-20-7 D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 114861-18-6 3-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-D-xylofuranose 

Downstream Products

• 256659-02-6 (4R,6S)-4-(2-(benzyloxy)ethyl)-6-ethynyl-2,2-dimethyl-1,3-dioxane 
• 115074-72-1 (S)-1-{(2R,4R,5S)-4-[(Z)-3-((4S,6R)-6-{(R)-3-[(4R,6S)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-1-hydroxy-propyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-2-methylsulfanyl-propenyl]-2-phenyl-[1,3]dioxan-5-yl}-propane-1,3-diol 
• 106947-26-6 (R)-3-[(4R,6S)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-1-{(4R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propan-1-ol 

Relevant academic research and scientific papers

Preparation method of atorvastatin measuring chain intermediate

The invention belongs to the technical field of organic chemistry and concretely relates to a preparation method of an atorvastatin measuring chain intermediate 2-((4R, 6S))-6-(2-(benzyloxy)ethyl)-2, 2-dimethyl-1, 3-dioxane-4-yl)ethylamine (I). The prepar

Synthesis and biophysical studies on 35-Deoxy amphotericin b methyl ester

The use of molecular editing in the elucidation of the mechanism of action of amphotericin B is presented. A modular strategy for the synthesis of amphotericin B and its designed analogues is developed, which relies on an efficient gram-scale synthesis of various subunits of amphotericin B. A novel method for the coupling of the mycosa-mine to the aglycone was identified. The implementation of the approach has enabled the preparation of 35-deoxy amphotericin B methyl ester. Investigation of the antifungal activity and efflux-inducing ability of this amphotericin B congener provided new clues to the role of the 35-hydroxy group and is consistent with the involvement of double barrel ion channels in causing electrolyte efflux. 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

Synthesis of 35-deoxy amphotericin B methyl ester: A strategy for molecular editing

(Chemical Presented) A modular strategy for the assembly of amphotericin B analogues with modifications in the macrolactone ring relies on the efficient gram-scale synthesis of all major and minor motifs of amphotericin B. Proof of concept has been achieved by the preparation of the 35-deoxy aglycone en route to the long-sought-after 35-deoxy analogue of amphotericin B.

A chiral β,δ-dioxo-ε-sulfinyl ester in a convergent enantioselective synthesis towards the C1-C13 polyol fragment of amphotericin B

This paper describes an efficient stereocontrolled and convergent approach towards the C1-C13 polyol fragment of amphotericin B. The strategy is based on the stereoselective reduction of a chiral β,γ-dioxo- ε-sulfinyl ester to obtain anti-or syn-1,3-diols.

Total Synthesis of Amphoteronolide B and Amphotericin B. 1. Strategy and Stereocontrolled Construction of Key Building Blocks

The retrosynthetic analysis and strategy for the total synthesis of amphotericin B (1) and amphoteronolide B (2) is discussed.Focusing on subtle and repeated structural units, a retrosynthetic scheme was constructed that led to the recognition of readily