106947-26-6

Upstream product

• 171524-11-1 (3S,5S)-7-(Benzyloxy)-1-iodo-3,5-O-isopropylideneheptane-3,5-diol 
• 214345-62-7 (4R,6R)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxane-4-carbaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 171599-00-1 2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethanol 
• 682777-33-9 tert-Butyl-[2-((4R,6R)-2,2-dimethyl-6-vinyl-[1,3]dioxan-4-yl)-ethoxy]-dimethyl-silane 
• 682777-25-9 2-{(4S,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethanol 
• 682777-27-1 {2-[(4R,6S)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethoxy}-tert-butyl-dimethyl-silane 
• 682777-31-7 tert-Butyl-(2-{(4R,6R)-2,2-dimethyl-6-[2-(2-nitro-phenylselanyl)-ethyl]-[1,3]dioxan-4-yl}-ethoxy)-dimethyl-silane 
• 106799-15-9 3,5-dideoxy-2,4-O-(1-methylethylidene)-6-O-(phenylmethyl)-L-erythro-hexose 
• 106799-19-3 dimethyl <<<(4R,6R)-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>ethyl>-2,2-dimethyl-m-dioxan-4-yl>carbonyl>methyl>phosphonate 

Downstream Products

• 115074-72-1 (S)-1-{(2R,4R,5S)-4-[(Z)-3-((4S,6R)-6-{(R)-3-[(4R,6S)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-1-hydroxy-propyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-2-methylsulfanyl-propenyl]-2-phenyl-[1,3]dioxan-5-yl}-propane-1,3-diol 

Relevant academic research and scientific papers

A convergent preparation of the C1-C13 fragment of amphotericin B from a single chiral precursor

A short, highly efficient, stereoconvergent synthesis of the polyolic chain, C1-C13, of the macrolide antibiotic amphotericin B is described. The key features of the synthesis are the use of a single chiral precursor for the establishment of the stereogenic centres in a short synthetic sequence, and the final alkyl lithium addition to the appropriate aldehyde, which showed high diastereoselectivity for the correct stereochemistry at the fifth stereogenic centre.