59862-55-4

Basic information

• Product Name: Ethanone, 1-(4-bromophenyl)-, oxime, (1E)-
• CAS NO: 59862-55-4
• Molecular Formula: C8H8BrNO
• Molecular Weight: 214.062
• Mol File: 59862-55-4.mol
• Article Data: 88

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-bromophenyl)-, oxime, (1E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-bromophenyl)-, oxime, (1E)-(59862-55-4)
• EPA Substance Registry System: Ethanone, 1-(4-bromophenyl)-, oxime, (1E)-(59862-55-4)

Safety Data

• Hazardous Substances Data: 59862-55-4(Hazardous Substances Data)

Upstream product

• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 108-86-1 bromobenzene 
• 99-90-1 para-bromoacetophenone 
• 107093-06-1 1-(4-Bromo-phenyl)-1-hydroxyamino-ethanol 

Downstream Products

• 20980-00-1 N-(4-bromophenyl)thioacetamide 
• 23794-89-0 C₁₆H₁₂BrF₃N₂O₂ 
• 64222-40-8 1-vinyl-2-(4-bromophenyl)pyrrole 
• 4995-11-3 2-(4-bromophenyl)-1H-pyrrole 
• 1068001-09-1 1-(4-bromophenyl)ethanone O-(2-hydroxy-3-phenoxypropyl)oxime 
• 13195-79-4 2,2-dibromo-1-(4-bromophenyl)ethan-1-one 
• 177750-12-8 N-{1-(4-bromophenyl)vinyl}acetamide 
• 98437-33-3 1-(4'-bromophenyl)-5-methyl-1H-tetrazole 
• 128094-33-7 3-(4-Bromo-phenyl)-5-((E)-styryl)-4,5-dihydro-isoxazole 
• 871720-04-6 N-[1-(4-bromo-phenyl)-ethyl]-2,2,2-trifluoro-acetamide 

Relevant articles and documents

Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters

Polysubstituted indoles are prevalent in pharmaceuticals, agrochemicals, and organic materials. Presented herein is the fact that polyfunctionalized indoles can be efficiently constructed from easily accessible oxime esters and aryl iodides, involving a palladium/norbornene synergistic synthesis. The reaction is enabled by a unique class of electrophiles in palladium/norbornene cooperative catalysis, which are oxime esters derived from simple ketone. The broad substrate scope and high functional group tolerance could make this method attractive for the synthesis of polysubstituted indoles.

C3-Arylation of indoles with aryl ketonesviaC-C/C-H activations

C3-Arylation of indoles with aryl ketones is accomplishedviapalladium-catalyzed ligand-promoted Ar-C(O) cleavage and subsequent C-H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good yields. Further introduction of an indole moiety into the natural products desoxyestrone and evodiamine demonstrate the synthetic utility of this protocol.

Rhodium(III)-Catalyzed Direct C-H Arylation of Various Acyclic Enamides with Arylsilanes

The stereoselective β-C(sp2)-H arylation of various acyclic enamides with arylsilanes via Rh(III)-catalyzed cross-coupling reaction was illustrated. The methodology was characterized by extraordinary efficacy and stereoselectivity, a wide scope of substrates, good functional group tolerance, and the adoption of environmentally friendly arylsilanes. The utility of this present method was evidenced by the gram-scale synthesis and further elaboration of the product. In addition, Rh(III)-catalyzed C-H activation is considered to be the critical step in the reaction mechanism.