106834-80-4Relevant academic research and scientific papers
Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses
Hu, Yanmei,Wang, Yuanxiang,Li, Fang,Ma, Chunlong,Wang, Jun
, p. 70 - 76 (2017/04/24)
The efficacy of current influenza vaccines and small molecule antiviral drugs is curtailed by the emerging of multidrug-resistant influenza viruses. As resistance to the only FDA-approved oral influenza antiviral, oseltamivir (Tamiflu), continues to rise, there is a clear need to develop the next-generation of antiviral drugs. Since more than 95% of current circulating influenza A viruses carry the S31N mutation in their M2 genes, the AM2-S31N mutant proton channel represents an attractive target for the development of broad-spectrum antivirals. In this study we report the design and synthesis of the first class of organosilanes that have potent antiviral activity against a panel of human clinical isolates of influenza A viruses, including viruses that are resistant to amantadine, oseltamivir, or both.
COMPOUNDS WHICH HAVE A PROTECTIVE ACTIVITY WITH RESPECT TO THE ACTION OF TOXINS AND OF VIRUSES WITH AN INTRACELLULAR MODE OF ACTION
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Paragraph 0175; 0176, (2016/04/19)
The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.
Iron-mediated intermolecular N-group transfer chemistry with olefinic substrates
Hennessy, Elisabeth T.,Liu, Richard Y.,Iovan, Diana A.,Duncan, Ryan A.,Betley, Theodore A.
, p. 1526 - 1532 (2014/03/21)
The dipyrrinato iron catalyst reacts with organic azides to generate a reactive, high-spin imido radical intermediate, distinct from nitrenoid or imido species commonly observed with low-spin transition metal complexes. The unique electronic structure of
