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106877-29-6

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106877-29-6 Usage

Description

5-METHYL-2-(TRIFLUOROMETHYL)ANILINE, also known as 3-amino-5-methylbenzotrifluoride, is a chemical compound with the formula C9H9F3N. It is a pale yellow liquid that serves as an intermediate in the production of various pharmaceuticals and agrochemicals. 5-METHYL-2-(TRIFLUOROMETHYL)ANILINE is primarily used as a building block in the synthesis of various organic chemicals, including dyes, pigments, and polymers. Additionally, it functions as a reagent in the production of pharmaceutical and agrochemical products. Due to its potential health hazards, 5-Methyl-2-(trifluoromethyl)aniline requires careful handling, storage, and use in a well-ventilated area with proper personal protective equipment.

Uses

Used in Pharmaceutical Industry:
5-METHYL-2-(TRIFLUOROMETHYL)ANILINE is used as an intermediate for the synthesis of various pharmaceutical products. Its unique chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-METHYL-2-(TRIFLUOROMETHYL)ANILINE is utilized as an intermediate in the production of agrochemicals. Its role in the synthesis of various agrochemicals aids in the development of effective solutions for agricultural applications, such as pest control and crop protection.
Used in Dye and Pigment Industry:
5-METHYL-2-(TRIFLUOROMETHYL)ANILINE is used as a building block in the synthesis of dyes and pigments. Its chemical properties enable the creation of a wide range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Polymer Industry:
5-METHYL-2-(TRIFLUOROMETHYL)ANILINE is also employed in the polymer industry as a monomer or a building block for the synthesis of polymers. Its incorporation into polymer chains can enhance the properties of the resulting materials, such as durability, stability, and resistance to environmental factors.
Used as a Reagent in Chemical Synthesis:
5-METHYL-2-(TRIFLUOROMETHYL)ANILINE serves as a reagent in various chemical synthesis processes. Its unique properties make it a valuable component in the production of a range of organic chemicals, contributing to the development of new materials and compounds with diverse applications.

Check Digit Verification of cas no

The CAS Registry Mumber 106877-29-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,8,7 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 106877-29:
(8*1)+(7*0)+(6*6)+(5*8)+(4*7)+(3*7)+(2*2)+(1*9)=146
146 % 10 = 6
So 106877-29-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H8F3N/c1-5-2-3-6(7(12)4-5)8(9,10)11/h2-4H,12H2,1H3

106877-29-6 Well-known Company Product Price

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  • Alfa Aesar

  • (H64407)  5-Methyl-2-(trifluoromethyl)aniline, 98%   

  • 106877-29-6

  • 250mg

  • 196.0CNY

  • Detail
  • Alfa Aesar

  • (H64407)  5-Methyl-2-(trifluoromethyl)aniline, 98%   

  • 106877-29-6

  • 1g

  • 588.0CNY

  • Detail
  • Alfa Aesar

  • (H64407)  5-Methyl-2-(trifluoromethyl)aniline, 98%   

  • 106877-29-6

  • 5g

  • 2352.0CNY

  • Detail

106877-29-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Methyl-2-(Trifluoromethyl)Aniline

1.2 Other means of identification

Product number -
Other names 5-Methyl-2-(trifluoromethyl)aniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106877-29-6 SDS

106877-29-6Downstream Products

106877-29-6Relevant articles and documents

Coordinating Activation Strategy-Induced Selective C?H Trifluoromethylation of Anilines

Xu, Jun,Cheng, Ke,Shen, Chao,Bai, Renren,Xie, Yuanyuan,Zhang, Pengfei

, p. 965 - 970 (2018)

A simple protocol for the synthesis of 2-(trifluoromethyl)aniline derivatives through a coordinating activation strategy was developed. The reaction showed good reactivity and gave the target products in moderate to good yields. Pleasingly, the directing group could be recovered in excellent yield. Furthermore, this strategy allowed efficient access to the synthesis of floctafenine. A single-electron-transfer mechanism was proposed to be responsible for this trifluoromethylation reaction.

Deoxofluorination of (Hetero)aromatic Acids

Alekseenko, Anatoliy N.,Bugera, Maksym Ya.,Gerus, Igor I.,Kiriakov, Oleksandr,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Pustovit, Yurii,Razhyk, Bohdan,Semenov, Sergey,Starova, Viktoriia S.,Tananaiko, Oksana Yu.,Tarasenko, Karen,Tolmachev, Andrei A.,Trofymchuk, Serhii,Zaporozhets, Olga A.

, p. 3110 - 3124 (2020/03/23)

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Discovery of 2-arylamino-4-(1-methyl-3-isopropylsulfonyl-4-pyrazol-amino)pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors

Zhang, Peilong,Dong, Jiaqiang,Zhong, Boyu,Zhang, Deyi,Jin, Can,Meng, Xuejing,Sun, Desheng,Xu, Xiangyuan,Zhou, Yong,Liang, Zhi,Ji, Minghua,Li, Hailong,Xu, Tao,Song, Guowei,Zhang, Ling,Chen, Gang,Yuan, Hongbin,Shih, Joe,Zhang, Ruihao,Hou, Guojun,Jin, Ying,Yang, Qiong

, p. 3738 - 3743 (2015/08/06)

Abstract A new series of 2,4-diamino pyrimidine derivatives with a sulfone-substituted pyrazole right side-chain were discovered as potent anaplastic lymphoma kinase inhibitors. Structure-activity relationship of the left side-chain on phenyl substitutions were explored which delivered many potent ALK inhibitors. Among them, 29a showed favorable pharmacokinetic profiles in rats and dogs together with significant antitumor efficacy in EML4-ALK fusion xenograft model. Graphical abstract

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