1069085-48-8

Basic information

• Product Name: 1-Benzyl-2-(difluoroMethyl)-4,5-dihydro-1H-iMidazole
• Synonyms: 1-Benzyl-2-(difluoroMethyl)-4,5-dihydro-1H-iMidazole
• CAS NO: 1069085-48-8
• Molecular Formula: C₁₁H₁₂F₂N₂
• Molecular Weight: 210
• Mol File: 1069085-48-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzyl-2-(difluoroMethyl)-4,5-dihydro-1H-iMidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-2-(difluoroMethyl)-4,5-dihydro-1H-iMidazole(1069085-48-8)
• EPA Substance Registry System: 1-Benzyl-2-(difluoroMethyl)-4,5-dihydro-1H-iMidazole(1069085-48-8)

Safety Data

• Hazardous Substances Data: 1069085-48-8(Hazardous Substances Data)

Usage

Chemical class

Imidazole compounds

Structure

Contains a benzyl and difluoromethyl group

Application

Used in pharmaceutical research and development

Potential medicinal properties

Being investigated for its potential as a drug candidate for the treatment of various diseases

Suitability

Its chemical structure and properties make it suitable for further study and potential application in the development of new medications.

Upstream product

• 381-73-7 Difluoroacetic acid 
• 4152-09-4 N-benzylethylenediamine 

Relevant articles and documents

A facile one-pot synthesis of 2-fluoroalkyl 1,3-imidazolines and 1,3-oxazolines through imidoyl halide intermediates

A facile one-pot procedure has been developed for the synthesis of 1,3-imidazolines and 1,3-oxazolines bearing fluorinated alkyl groups at the 2-position. The reaction involves the condensation of N-monosubstituted ethane-1,2-diamines or 2-aminoethanols with a fluorinated carboxylic acid in the presence of PPh3/CX4. The proposed mechanism is that the amide intermediates were initially formed, and then converted to the imidoyl halide intermediates in the presence of PPh3/CX4, followed by rapid intramolecular cyclization to 1,3-diazoline products. This protocol allows for the synthesis of 2-bromodifluoromethyl-1,3-imidazoline, a useful CF2Br-heterocyclic building block, which can be used for the synthesis of gem-difluoromethylene linked compounds.