1069086-87-8Relevant academic research and scientific papers
Development of a tandem base-catalyzed, triphenylphosphine-mediated disulfide reduction-Michael addition
Bartolozzi, Alessandra,Foudoulakis, Hope M.,Cole, Bridget M.
experimental part, p. 2023 - 2032 (2009/04/03)
A tandem disulfide reduction-Michael addition was developed using both free and polymer-bound triphenylphosphine as the reducing agent. The procedure was applied to intermolecular systems for the synthesis of arylsulfanyl- and alkylsulfanyl-substi-tuted p
Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones
Bandarage, Upul K.,Wang, Tiansheng,Come, Jon H.,Perola, Emanuele,Wei, Yunyi,Rao, B. Govinda
, p. 44 - 48 (2008/09/17)
A series of potent thiol-containing aryl sulfone TACE inhibitors were designed and synthesized. The SAR and MMP selectivity of the series were investigated. In particular, compound 8b showed excellent in vitro potency against the isolated enzyme and good selectivity over MMP-2, -7, -8, -9, and -13. The X-ray structure of 8b in complex with TACE was also obtained.
