15015-57-3

Basic information

• Product Name: BIS(4-HYDROXYPHENYL)DISULFIDE
• Synonyms: BIS(4-HYDROXYPHENYL)DISULFIDE;4,4'-DIHYDROXY DIPHENYL DISULFIDE;4,4'-DIHYDROXYDIPHENYLDISULPHIDE;4,4'-Disulfanediyldiphenol;4,4'-Dithiodiphenol;4,4'-Dihydroxy diphe;4,4'-Dihydroxydiphenyl Disulfide 4,4'-Dithiodiphenol;4,4'-Dihydroxydiphenyl Disulfide 4
• CAS NO: 15015-57-3
• Molecular Formula: C₁₂H₁₀O₂S₂
• Molecular Weight: 250.34
• Product Categories: Miscellaneous;pharmacetical
• Mol File: 15015-57-3.mol
• Article Data: 48

Chemical Properties

• Melting Point: 150.0 to 154.0 °C
• Boiling Point: 437.9 °C at 760 mmHg
• Flash Point: 212.5 °C
• Appearance: /
• Density: 1.449 g/cm³
• Vapor Pressure: 2.8E-08mmHg at 25°C
• Refractive Index: 1.752
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 9.01±0.26(Predicted)
• CAS DataBase Reference: BIS(4-HYDROXYPHENYL)DISULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(4-HYDROXYPHENYL)DISULFIDE(15015-57-3)
• EPA Substance Registry System: BIS(4-HYDROXYPHENYL)DISULFIDE(15015-57-3)

Safety Data

• Hazardous Substances Data: 15015-57-3(Hazardous Substances Data)

Usage

General Description

BIS(4-HYDROXYPHENYL)DISULFIDE, also known as Bisphenol A, is a chemical compound consisting of two 4-hydroxyphenyl groups linked by a disulfide bond. It is commonly used as a cross-linking agent or vulcanizing agent in the production of rubber and plastic materials. It can also be found in some cosmetics and personal care products. However, concerns have been raised about its potential health risks, as some studies suggest that it may act as an endocrine disruptor and have toxic effects on the reproductive system. As a result, there has been a push to limit or eliminate the use of BIS(4-HYDROXYPHENYL)DISULFIDE in consumer products.

InChI:InChI=1/C12H10O2S2/c13-9-1-5-11(6-2-9)15-16-12-7-3-10(14)4-8-12/h1-8,13-14H

Upstream product

• 637-89-8 4-sulfanylphenol 
• 70-18-8 GLUTATHIONE 
• 1176996-13-6 (E)-4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one 
• 1176996-15-8 (Z)-4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one 
• 540-38-5 p-Iodophenol 
• 107-03-9 1-thiopropane 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 3885-04-9 4-acetoxybenzenesulfonic acid sodium salt 
• 76372-46-8 1-acetoxy-4-acetylsulfanyl-benzene 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 
• 108-95-2 phenol 
• 3774-52-5 4-thiocyanato-phenol 
• 19089-85-1 p-diazophenol 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 163445-51-0 Bis(4-isopropyloxyphenyl)disulfide 
• 31121-13-8 bis-(4-ethoxy-phenyl)-disulfide 
• 168069-10-1 Fe2(CO)6(μ-C6H4-4-OH)2 * C6H6 
• 1069086-87-8 3-[(4-hydroxyphenyl)sulfanyl]cyclopentanone 
• 1069086-82-3 2-(dimethylamino)ethyl 3-[(4-hydroxyphenyl)sulfanyl]-2-methylpropanoate 
• 1069086-80-1 methyl 2-acetamido-3-[(4-hydroxyphenyl)sulfanyl]propanoate 
• 1069086-86-7 3-{[(4-hydroxyphenyl)sulfanyl]methyl}bicyclo[2.2.1]heptan-2-one 
• 121829-88-7 methyl 3-[(4-hydroxyphenyl)sulfanyl]-2-methylpropanoate 
• 179246-19-6 bis{4-[(phenylmethyl)oxy]phenyl} disulfide 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 
• 326921-47-5 bis-(4-acetoxy-phenyl)-disulfide 
• 109697-21-4 trithioarsenous acid tris-(4-hydroxy-phenyl ester) 
• 189822-72-8 2-benzothiazolyl 4-hydroxyphenyl disulfide 

Relevant articles and documents

Syntheses of alkylated malonates on a traceless linker derived soluble polymer support

A new traceless soluble polymeric linker and a corresponding alkylating strategy has been developed. Dimethyl malonate was alkylated with a variety of polymeric halides and these resulting polymer bound malonates underwent further alkylation with addition

Substituted o-Aminophenols as Redox-Mediators in the Thiol Oxidation to Unsymmetrical Disulfides

A number of substituted o-aminophenols has been investigated as redox mediators of the thiol oxidation to disulfides. The electrooxidation of o-aminophenols leads to the corresponding o-iminobenzoquinones. These compounds react with thiols in the solution with a formation of disulfides. It was established that the use of 4,6-di-tert-butyl-2-(tert-butylamino)phenol as a redox mediator can reduce the overpotential of the thiol oxidation by 0.2-1.4 V depending on the nature of the coupling thiols. The unsymmetrical disulfides with alkyl, aryl, and heteroaryl substituents were obtained as the result of the indirect electrosynthesis.

Green Aerobic Oxidation of Thiols to Disulfides by Flavin-Iodine Coupled Organocatalysis

Coupled catalysis using a riboflavin-derived organocatalyst and molecular iodine successfully promoted the aerobic oxidation of thiols to disulfides under metal-free mild conditions. The activation of molecular oxygen occurred smoothly at room temperature through the transfer of electrons from the iodine catalyst to the biomimetic flavin catalyst, forming the basis for a green oxidative synthesis of disulfides from thiols.

Preparation method of symmetric disulfide bond-containing compound

The method comprises the following steps: adding a raw material and an oxidant to a reaction bottle containing a solvent; reacting 23W - 85W under the irradiation of 12 - 24h energy-saving lamps; and purifying the reaction product to obtain symmetrical disulfide bond-containing compounds. The raw material is mercaptan or thiophenol. The oxidizing agent is trichlorobromomethane, and the solvent is tetrahydrofuran. The method has the advantages of simple operation, high yield (70 - 90%), wide applicability, cheap and easily available raw materials, and provides a better way for the synthesis and production of symmetrical disulfide bond-containing compounds.