1069138-44-8Relevant academic research and scientific papers
Synthesis, activity and structure-activity relationship of noroviral protease inhibitors
Deng, Lisheng,Muhaxhiri, Zana,Estes, Mary K.,Palzkill, Timothy,Venkataram Prasad,Song, Yongcheng
, p. 1354 - 1359 (2013)
The protease of norovirus, an important human pathogen, is essential for the viral replication and, therefore, represents a potential drug target. A series of tripeptide-based inhibitors of the protease were designed, synthesized and tested, among which several potent inhibitors were identified with K i values as low as 75 nM. The structure-activity relationships of these inhibitors are discussed.
Tetrazole analogues of aspartic, glutamic and α-aminoadipic acids and their derivatives with tetrazole ring in side chains useful for solid-phase peptide synthesis
Manturewicz,Grzonka
, p. 2121 - 2131 (2008/09/18)
Tetrazole analogues of Fmoc-aspartic, -glutamic and -α-aminoadipic acids with acidic tetrazolyl group in side chains suitable for solid-phase peptide synthesis were obtained. Moreover, the appropriate derivatives of aspartic and glutamic acids containing tetrazole ring methylated in position N1 or N2 were synthesized as well.
