MedChemComm p. 1354 - 1359 (2013)
Update date:2022-07-30
Topics:
Deng, Lisheng
Muhaxhiri, Zana
Estes, Mary K.
Palzkill, Timothy
Venkataram Prasad
Song, Yongcheng
The protease of norovirus, an important human pathogen, is essential for the viral replication and, therefore, represents a potential drug target. A series of tripeptide-based inhibitors of the protease were designed, synthesized and tested, among which several potent inhibitors were identified with K i values as low as 75 nM. The structure-activity relationships of these inhibitors are discussed.
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