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Usage

Uses

Used in Dermatology:
Fluocinolone Acetonide-21-carboxylic Acid is used as a topical medication for the treatment of various skin conditions characterized by inflammation, itching, and redness. Its application in dermatology is due to its ability to reduce skin inflammation and provide relief from itching, making it an effective treatment for conditions such as eczema, psoriasis, and contact dermatitis.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Fluocinolone Acetonide-21-carboxylic Acid is used as an active ingredient in the formulation of corticosteroid creams, ointments, and gels. Its incorporation into these formulations is due to its potent anti-inflammatory and immunosuppressive effects, which help to alleviate the symptoms of various skin disorders and improve the patient's quality of life.
Used in Research and Development:
Fluocinolone Acetonide-21-carboxylic Acid is also utilized in research and development for the discovery of new therapeutic agents with improved efficacy and reduced side effects. Its unique properties make it a valuable compound for studying the mechanisms of inflammation and immune regulation, potentially leading to the development of novel treatments for a wide range of inflammatory and autoimmune diseases.

Upstream product

• 67-73-2 fluocinolone Acetonide 
• 13242-30-3 2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoacetaldehyde 

Relevant academic research and scientific papers

A concise access to a new class of selective anti-inflammatory steroid derivatives

The 17β-thiomethyl-16α,17α-ketal motif of a new class of selective anti-inflammatory androstane derivatives useful in the treatment of asthma is readily constructed by a new radical degradation of the corticosteroid side chain.

Soft drugs based on hydrocortisone: The inactive metabolite approach and its application to steroidal antiinflammatory agents

Purpose. The soft drug approach was applied to the design of analogs of highly potent synthetic steroids but with a metabolically labile ester group which at the same time served as an activating group. Methods. Several structural modifications of soft antiinflammatory steroids were synthesized and tested in several assays of biological activity. The hydrolytic stability of the compounds was also determined. Results. One of the compounds synthesized was determined to be a very potent steroid and had a highly significant separation of topical from systemic activity. However, the compound demonstrated greater than expected stability in the hydrolysis studies. Conclusions. The goal of the soft drug approach has been achieved with the development of a highly potent drug which displays little or no systemic activity as measured in the tests presented here. The anticipated hydrolytic instability of the compounds was not corroborated; however, in view of other results, the interpretation is allowed that the rapid hydrolysis of the unbound fraction of the drug is an important factor in its lack of systemic effects.