106943-05-9

Basic information

• Product Name: N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride
• Synonyms: N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride
• CAS NO: 106943-05-9
• Molecular Weight: 372.774
• Mol File: 106943-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride(106943-05-9)
• EPA Substance Registry System: N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride(106943-05-9)

Safety Data

• Hazardous Substances Data: 106943-05-9(Hazardous Substances Data)

Upstream product

• 101468-97-7 N-benzoyl-(4'-nitro)phenylalanine 
• 98-88-4 benzoyl chloride 
• 106942-32-9 2-phenyl-4-<(4-nitro)phenylmethyl>-5(4H)-oxazolone 
• 106942-39-6 4-(4-Nitro-benzyl)-2-phenyl-4-(2,2,2-trifluoro-acetyl)-4H-oxazol-5-one 
• 1991-83-9 4-nitrophenylalanine 
• 106746-00-3 N-[3,3,3-Trifluoro-2-oxo-(4-nitrophenylmethyl)propyl]benzamide 

Relevant articles and documents

SYNTHESIS OF FLUORINATED α-AMINO KETONES PART I: α-BENZAMIDOALKYL MONO- DI- AND TRIFLUOROMETHYL KETONES

2-Phenyl-5(4H)-oxazolones, obtained from α-amino acids, are reacted with di- and trifluoro acetic anhydride by a modified Dakin-West procedure to yield in a one-pot reaction α-benzamidoalkyl-di- and trifluoromethyl ketones in good yields.The monofluoromethyl analogues were also prepared from α-amino acids, however the use of the highly toxic fluoroacetic anhydride was avoided.The key step is the halogen exchange reaction on the corresponding bromomethyl ketone.