106950-01-0Relevant articles and documents
Method of coupling, and the coupling method using the aromatic group-substituted heterocyclic compound
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Paragraph 0247-0254; 0263-0266, (2020/09/17)
Provided is an easy method (coupling method) capable of easily synthesizing a compound group in which aromatic molecules and aromatic molecules are coupled, a compound group in which aromatic molecules and alkene molecules are coupled, and the like without producing halogen waste and without the need to use scarce and expensive palladium. A compound (A) shown by general formula (A): Ar-H and a compound (B1) shown by general formula (B1): RaOCO-Ar', a compound (B2) shown by general formula (B2): RbCH=C(Ar")2, or a compound (B3) shown by general formula (B3): RcOCOCH=C(Ar")2 are reacted in the presence of a nickel compound.
Straightforward microwave-assisted synthesis of 2-thiazolines using Lawesson's reagent under solvent-free conditions
Seijas, Julio A.,Vázquez-Tato, M. Pilar,Crecente-Campo, José
, p. 9280 - 9285 (2008/12/21)
2-Thiazolines are synthesized from carboxylic acids and 1,2-aminoalcohols in the presence of Lawesson's reagent under solventless conditions. The developed method is valid for either substituted or unsubstituted aminoalcohols and a wide variety of aromatic, heteroaromatic and aliphatic carboxylic acids; thus it constitutes a general synthetic method for these kinds of compounds. The role of Lawesson's reagent is dual: to transform the 1,2-aminoalcohol into 1,2-aminothiol and to activate its reaction with the carboxylic acid leading to the formation of a thiazoline ring, all in one pot.
