106972-47-8

Basic information

• Product Name: C₄₇H₆₄O₃
• Synonyms: C₄₇H₆₄O₃
• CAS NO: 106972-47-8
• Molecular Weight: 677.023
• Mol File: 106972-47-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₄₇H₆₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₇H₆₄O₃(106972-47-8)
• EPA Substance Registry System: C₄₇H₆₄O₃(106972-47-8)

Safety Data

• Hazardous Substances Data: 106972-47-8(Hazardous Substances Data)

Upstream product

• 86334-56-7 1-octadecyloxy-3-trityloxy-propan-2-ol 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 16725-43-2 4-(n-octadecyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 76-83-5 trityl chloride 
• 544-62-7 batyl alcohol 

Downstream Products

• 51134-45-3 2-(benzyloxy)-3-(octadecyloxy)propyl 2-bromoethyl phosphate 
• 72490-82-5 2-hydroxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate 
• 43043-61-4 C₃₃H₆₂NO₆P 
• 86008-21-1 2-(benzyloxy)-3-(octadecyloxy)-1-propanol 

Relevant articles and documents

Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids

Two series of erlotinib-alkylphospholipid hybrids were prepared and evaluated for their antiproliferative activities against a panel of four cell lines representing lung, breast, liver and skin cancers using erlotinib and miltefosine as reference standards. Amide analogs elicited more enhanced cytotoxic activity than analogous esters. Amide derivatives 8d and 8e exhibited promising broad-spectrum antiproliferative activity and higher efficacy than reference erlotinib and miltefosine. Their cellular GI50 values was in the ranges of 24.7–46.9 μM and 26.8–43.1 μM for 8e and 8d respectively. Assay results of the inhibitory activity of the prepared compounds on EGFR kinase reaction and Akt phosphorylation in conjugation with statistical correlation analysis indicated that other mechanisms might contribute to their elicited cytotoxicities. In addition, statistical correlation analysis revealed that mechanisms of elicited cytotoxicities for amide series might be different from ester series. In addition, correlation analysis indicated variations in the mechanisms according to the types of cell line.