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Usage

Uses

Used in Pharmaceutical Industry:
2-(2-isopropylphenyl)propan-2-ol is used as a nasal decongestant for the treatment of nasal congestion caused by allergies, hay fever, and the common cold. Its application reason is due to its capability to narrow the blood vessels in the nasal passages, which reduces swelling and congestion, offering temporary relief to the user.

Upstream product

• 7073-94-1 1-bromo-2-isopropylbenzene 
• 67-64-1 acetone 
• 105337-82-4 ethyl 2-isopropylbenzoate 

Downstream Products

• 879395-44-5 N,N'-bis-(2,3-diisopropyl-phenyl)-1,2-diphenyl-ethane-1,2-diamine 
• 879395-41-2 1-bromo-2-isopropenyl-3-isopropyl-benzene 
• 879395-43-4 1-bromo-2,3-diisopropylbenzene 
• 879395-40-1 2-(2-bromo-6-isopropyl-phenyl)-propan-2-ol 
• 105474-21-3 1-(α-chloro-isopropyl)-2-isopropyl-benzene 

Relevant academic research and scientific papers

Stereolabile and configurationally stable atropisomers of hindered aryl carbinols

Carbinols of the Ar-C(OH)R2 type, Ar being o-isopropylphenyl, exist as stereolabile syn-clinal (sc) and anti-periplanar (ap) atropisomers when R = Me, Et, i-Pr. In the latter compound, the major atropisomer also comprises two enantiomeric forms that interchange with a barrier of 6.4 kcal mol -1. X-ray diffraction, NOE experiments, and ab initio calculations indicate that the sc-atropisomer is the more stable form when R = Me, i-Pr, t-Bu but is the less stable one when R = Et. NMR spectra at variable temperature allowed the determination of the barriers for the interconversion of the sc- into the ap-atropisomers (ΔG? = 7.6, 8.8, and 13.5 kcal mol -1 for Me, Et, i-Pr, respectively). When R is a tert-butyl group, the two atropisomers are configurationally stable: the ap-atropisomer is obtained as the kinetic controlled compound, which can be transformed into the thermodynamically more stable sc-atropisomer with a free energy of activation of 29.3 kcal mol-1. Both atropisomers exhibit restricted rotation of the tert-butyl moiety, the corresponding ΔG? values being 9.4 and 8.8 kcal mol-1 for the sc- and ap-atropisomer, respectively.

Highly active chiral ruthenium catalysts for asymmetric ring-closing olefin metathesis

The synthesis of olefin metathesis catalysts containing chiral, monodentate N-heterocyclic carbenes and their application to asymmetric ring-closing metathesis (ARCM) are reported. These catalysts retain the high levels of reactivity found in the related