1070-13-9Relevant articles and documents
Formal synthesis of brivaracetam: A key to construct the pyrrolidone scaffold using Pd-catalyzed oxidative cyclization and ring-closing metathesis reaction
Chavan, Subhash P.,Kawale, Sanket A.,Chavan, Prakash N.
, (2019)
A short and efficient synthetic approach for brivaracetam has been accomplished via two different routes which utilize Pd-catalyzed oxidative cyclization and ring-closing metathesis (RCM) as the key reaction. These two routes are novel, simple, scalable and rely on (E)-pent-2-en-1-ol and valeraldehyde as a commercially available starting material to yield brivaracetam with good overall yield.
Three Ways Aliphatic Aldehydes React with Nonstabilized Azomethine Ylides
Buev, Evgeny M.,Gorbunova, Evgeniya V.,Moshkin, Vladimir S.,Sosnovskikh, Vyacheslav Y.
, p. 343 - 348 (2020)
Aliphatic aldehydes readily react with nonstabilized azomethine ylides in one of the three ways to give oxazolidines, pyrrolidines, or Mannich bases, depending on the structure of the starting compound and the reaction conditions. The use of N -(methoxymethyl)- N -[(trimethylsilyl)methyl]benzylamine in DMF provided 5-alkyloxazolidines in 40-97percent yields. On the other hand, three-component reactions of aliphatic aldehydes bearing one α-hydrogen with N -methyl(benzyl)glycine and formaldehyde gives Mannich bases in yields of 47-98percent. A similar reaction of aldehydes bearing branched alkyl groups and two hydrogen atoms at the α-position proceeds as a domino process that gives 3-alkyl-3-formylpyrrolidines in yields of 34-93percent.
Substituted thiophene and benzoquinone and isoxazole compound and its preparation method and application
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Paragraph 0176; 0177, (2017/07/23)
The invention relates to the technical field of medicine, and provides substituted tricyclo-quinone compounds and pharmaceutically acceptable salts thereof. The structural general formula of the substituted aromatic tetracyclic compounds is disclosed in the specification. The invention also provides a preparation method of the compounds and application of the compounds in preparation of antifungal drugs.
