354529-98-9

Basic information

• Product Name: 1-phenyl-2-propyl-2-propen-1-one
• Synonyms: 1-phenyl-2-propyl-2-propen-1-one
• CAS NO: 354529-98-9
• Molecular Weight: 174.243
• Mol File: 354529-98-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1-phenyl-2-propyl-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-propyl-2-propen-1-one(354529-98-9)
• EPA Substance Registry System: 1-phenyl-2-propyl-2-propen-1-one(354529-98-9)

Safety Data

• Hazardous Substances Data: 354529-98-9(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 124-38-9 carbon dioxide 
• 1009-14-9 phenyl butyl ketone 
• 67-68-5 dimethyl sulfoxide 
• 67-56-1 methanol 
• 15121-79-6 2-(hydroxymethyl)-1-phenylprop-2-en-1-one 
• 1070-13-9 2-methylidenepentanal 
• 108-86-1 bromobenzene 
• 100-97-0 hexamethylenetetramine 
• 91962-95-7 α-acetoxymethyl phenyl vinyl ketone 
• 925-90-6 ethylmagnesium bromide 
• 50-00-0 formaldehyd 

Downstream Products

• 92013-10-0 2-propylindan-1-one 
• 31366-05-9 (±)2-methyl-1-phenylpentan-1-one 
• 1629211-93-3 C₃₀H₃₆N₂O 

Relevant articles and documents

Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents

An enantioselective epoxidation of α-substituted vinyl ketones was realized to construct the key epoxide intermediates for the synthesis of various triazole antifungal agents. The reaction proceeded efficiently in high yields with good enantioselectivities by employing a chiral N,N′-dioxide/ScIII complex as the chiral catalyst and 35% aq. H2O2 as the oxidant. It enabled the facile transformation for optically active isavuconazole, efinaconazole, and other potential antifungal agents.

Transition-Metal-Free Reductive Deoxygenative Olefination with CO2

A new transition-metal-free reductive deoxygenative olefination of phosphorus ylides with CO2, an abundant and sustainable C1 chemical feedstock, is described. This catalytic CO2 fixation afforded β-unsubstituted acrylates and vinyl ketones in good yields with broad scope and good functional group tolerance under mild reaction conditions. Cost-effective and easily handled polymethylhydrosiloxane was used as a reductant. Bis(silyl)acetal was proved to be the key intermediate in this reductive functionalization of CO2.

Transition metal-free C(sp3)-H bond coupling among three methyl groups

A coupling of multiple C(sp3)-H bonds of the methyl group in methyl ketones with dimethyl sulfoxide is developed. This coupling allows the direct C(sp3)-H bond coupling among three methyl groups and affords one C-C bond and one CC bond under transition metal-free conditions. The value-added cyclized 3-methylthiomethyl chroman-4-ones can be synthesized through this method. A plausible mechanism is proposed.