107007-94-3

Basic information

• Product Name: 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate
• Synonyms: 1H-Indazole-3-carboxylic acid, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-; 8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl 1H-indazole-3-carboxylate
• CAS NO: 107007-94-3
• Molecular Formula: C₁₆H₁₉N₃O₂
• Molecular Weight: 285.341003
• Mol File: 107007-94-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate(107007-94-3)
• EPA Substance Registry System: 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate(107007-94-3)

Safety Data

• Hazardous Substances Data: 107007-94-3(Hazardous Substances Data)

Usage

General Description

8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate is a chemical compound that is derived from the combination of 8-methyl-8-azabicyclo[3.2.1]octane and 2H-indazole-3-carboxylic acid. It is a bicyclic compound that contains a nitrogen-containing heterocycle, and has potential applications in medicinal chemistry and drug development. 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate is being researched for its potential pharmacological effects, including its interactions with various neurotransmitter receptors in the central nervous system. Its unique chemical structure makes it a promising candidate for the development of new pharmaceuticals and therapeutic agents.

Upstream product

• 4498-67-3 1H-Indazole-3-carboxylic acid 
• 120-29-6 3-tropanol 
• 115660-68-9 diindazolo<2,3-a,2',3'-d>pyrazine-7,14-dione 

Relevant articles and documents

5-Hydroxytryptamine (5-HT3) Receptor Antagonists. 1. Indazole and Indolizine-3-carboxylic Acid Derivatives

Metoclopramide (1) is a gastric motility stimulant and a weak dopamine and 5-HT3 receptor antagonist.Conformational restriction of the (diethylamino)ethyl side chain of 1 in the form of the azabicyclic tropane gave 3, a very potent gastric motility stimulant and 5-HT3 receptor antagonist but devoid of significant dopamine receptor antagonist properties.Subsequent alteration of the aromatic nucleus led to the identification of indazoles 6a-h, and 1- and 3-indolizines 7b-d, and 8, and imidazopyridines 9 and 10, as potent 5-HT3 receptor antagonists devoid ofeither dopamine antagonist or gastric motility stimulatory properties.Further conformational restriction of the side chain identified quinuclidine 11 and isoquinuclidine 12 as potent 5-HT3 receptor antagonists which mimic the distorted chair conformation of the tropane with, in the case of 11, the N-methyl group axial.From these series, 6g (BRL 43694) was found to be both potent and selective and has been shown to be a very effective antiemetic agent against cytotoxic drug induced emesis both in the ferret and in man.