107007-94-3 Usage
Uses
Used in Medicinal Chemistry:
8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate is utilized as a key intermediate in the synthesis of various pharmaceuticals due to its unique bicyclic structure and nitrogen-containing heterocycle, which can be leveraged to modulate the activity of different biological targets.
Used in Drug Development:
In the pharmaceutical industry, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate is employed as a scaffold for the development of new drugs, capitalizing on its potential to interact with neurotransmitter receptors in the central nervous system, thereby offering avenues for the treatment of neurological disorders and other conditions.
Used in Research and Development:
8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate serves as a subject of research for its pharmacological effects, with ongoing studies aimed at understanding its interactions with neurotransmitter receptors, which could lead to the discovery of new mechanisms of action and therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 107007-94-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,0,0 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 107007-94:
(8*1)+(7*0)+(6*7)+(5*0)+(4*0)+(3*7)+(2*9)+(1*4)=93
93 % 10 = 3
So 107007-94-3 is a valid CAS Registry Number.
107007-94-3Relevant academic research and scientific papers
5-Hydroxytryptamine (5-HT3) Receptor Antagonists. 1. Indazole and Indolizine-3-carboxylic Acid Derivatives
Bermudez, Jose,Fake, Charles S.,Joiner, Graham F.,Joiner, Karen A.,King, Frank D.,et al.
, p. 1924 - 1929 (2007/10/02)
Metoclopramide (1) is a gastric motility stimulant and a weak dopamine and 5-HT3 receptor antagonist.Conformational restriction of the (diethylamino)ethyl side chain of 1 in the form of the azabicyclic tropane gave 3, a very potent gastric motility stimulant and 5-HT3 receptor antagonist but devoid of significant dopamine receptor antagonist properties.Subsequent alteration of the aromatic nucleus led to the identification of indazoles 6a-h, and 1- and 3-indolizines 7b-d, and 8, and imidazopyridines 9 and 10, as potent 5-HT3 receptor antagonists devoid ofeither dopamine antagonist or gastric motility stimulatory properties.Further conformational restriction of the side chain identified quinuclidine 11 and isoquinuclidine 12 as potent 5-HT3 receptor antagonists which mimic the distorted chair conformation of the tropane with, in the case of 11, the N-methyl group axial.From these series, 6g (BRL 43694) was found to be both potent and selective and has been shown to be a very effective antiemetic agent against cytotoxic drug induced emesis both in the ferret and in man.
