107036-23-7

Basic information

• Product Name: Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester
• Synonyms: Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester
• CAS NO: 107036-23-7
• Molecular Weight: 388.848
• Mol File: 107036-23-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester(107036-23-7)
• EPA Substance Registry System: Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester(107036-23-7)

Safety Data

• Hazardous Substances Data: 107036-23-7(Hazardous Substances Data)

Upstream product

• 1756-65-6 (2R*,3S*)-2,3-bis(4-methoxyphenyl)pentanoic acid 
• 83303-72-4 (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanoic acid 
• 83303-74-6 (2R*,3S*)-2,3-bis(4-acetoxyphenyl)pentanoic acid 

Downstream Products

• 107036-27-1 3-bromopropyl (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanoate 
• 107036-28-2 3-iodoethyl (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanoate 
• 107036-11-3 (2R*,3S*)-1-<2,3-bis(4-hydroxyphenyl)-1-pentanoyl>aziridine 
• 83303-80-4 (3R*,4S*)-3,4-bis(4-hydroxyphenyl)-5-nonanone 
• 83303-82-6 (3R*,4S*)-3,4-bis(4-hydroxyphenyl)-2-hexanone 
• 107036-24-8 3-bromopropyl (2R*,3S*)-2,3-bis(4-acetoxyphenyl)pentanoate 
• 107036-25-9 3-iodoethyl (2R*,3S*)-2,3-bis(4-acetoxyphenyl)pentanoate 
• 107036-26-0 (2R*,3S*)-1-<2,3-bis(4-acetoxyphenyl)-1-pentanoyl>aziridine 

Relevant articles and documents

Nonsteroidal Estrogens: Synthesis and Estrogen Receptor Binding Affinity of Derivatives of (3R*,4S*)-3,4-Bis(4-hydroxyphenyl)hexane (Hexestrol) and (2R*,3S*)-2,3-Bis(4-hydroxyphenyl)pentane (Norhexestrol) Functionalized on the Side Chain

A series of nonsteroidal, side-chain functionalized estrogens based on (3R*,4S*)-3,4-bis(4-hydroxyphenyl)hexane (hexestrol) and (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentane (norhexestrol) has been prepared; these include amide, diazo ketone, ester, alcohol, ketone, fluoro,bromo, iodo, and saturated hydrocarbon derivatives.Analysis of the binding affinity of these compounds to the uterine estrogen receptor, measured by competitive binding assay, reveals trends that can be related to the steric size, the hydrophobicity, and the hydrogen bond accepting character of the side-chain substituents.Comparison of binding affinities between norhexestrol and hexestrol derivatives indicates that, in general, the norhexestrols show significantly higher receptor binding affinities, making this series of compounds ideally suited as functional probes for the estrogen receptor.