55696-50-9

Usage

InChI:InChI=1/C12H13NO2/c1-12(2,3)15-11(14)10-6-4-9(8-13)5-7-10/h4-7H,1-3H3

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 75-65-0 tert-butyl alcohol 
• 619-65-8 4-cyanobenzoic Acid 
• 115-11-7 isobutene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 171364-82-2 4-cyanophenylboronic acid pinacol ester 
• 126747-14-6 4-cyanophenylboronic acid 
• 201230-82-2 carbon monoxide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 865-48-5 sodium t-butanolate 
• 105-07-7 4-cyanobenzaldehyde 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 

Downstream Products

• 184576-27-0 tert-butyl 4-[amino(hydroxyimino)methyl]benzoate 
• 340736-83-6 4-(1,2,4-oxadiazol-3-yl)benzoic acid 
• 340736-86-9 4-(5-methoxy-1,2,4-oxadiazol-3-yl)benzoic acid 
• 340736-78-9 4-(2-oxo-2,3-dihydro-1,2λ⁴,3,5-oxathiadiazol-4-yl)benzoic acid 
• 340736-79-0 tert-butyl 4-(1,2,4-oxadiazol-3-yl)benzoate 
• 340736-84-7 4-(5-cyano-1,2,4-oxadiazol-3-yl)benzoic acid 
• 340736-77-8 tert-butyl 4-(2-oxo-2,3-dihydro-1,2λ⁴,3,5-oxathiadiazol-4-yl)benzoate 
• 340736-85-8 tert-butyl 4-(5-methoxy-1,2,4-oxadiazol-3-yl)benzoate 
• 340736-82-5 tert-butyl 4-(5-cyano-1,2,4-oxadiazol-3-yl)benzoate 
• 340736-81-4 tert-butyl 4-(5-carbamoyl-1,2,4-oxadiazol-3-yl)benzoate 
• 340736-80-3 ethyl 3-[4-(tert-butoxycarbonyl)phenyl]-1,2,4-oxadiazole-5-carboxylate 
• 340736-49-4 methyl 2-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-1-[(2S)-3-(4-methoxyphenyl)-2-[[4-(1,2,4-oxadiazol-3-yl)benzoyl]amino]propanoyl]-3-oxopiperazinyl]acetate 
• 340736-45-0 methyl 2-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-1-[(2S)-3-(4-methoxyphenyl)-2-[[4-(2-oxo-2,3-dihydro-1,2,λ⁴,3,5-oxathiadiazol-3-yl)benzoyl]amino]propanoyl]-3-oxopiperazinyl]acetate 
• 340736-51-8 methyl 2-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-1-[[(2S)-2-[4-(5-methoxy-1,2,4-oxadiazol-3-yl)benzoyl]amino]-3-(methoxyphenyl)propanoyl]-3-oxopiperazinyl]acetate 

Relevant academic research and scientific papers

Visible light-induced transformation of aldehydes to esters, carboxylic anhydrides and amides

A transition metal- and organophotocatalyst free synthesis of esters, carboxylic anhydrides and amides from aldehydes induced by visible-light has been reported. The proposed methodology can be carried out by the use of sunlight or artificial visible light as a blue LED source. The methodology has a very broad applicability and the desired products are obtained in very satisfactory yields.

Preparation method of Na molecular fluorescent intermediate and preparation method of Na molecular fluorescent sensor

The invention provides a preparation method of a Na molecular fluorescent intermediate and a preparation method of a Na molecular fluorescent sensor. The Na molecular fluorescent intermediatehas a structure as shown in a formula I. The preparation method of the Na molecular fluorescent intermediate comprises the following steps: S1, carrying out a substitution reaction on o-anisidineand alpha-methyl haloacetate to obtain a compound 2; S2, carrying out a reduction reaction on the compound 2 to obtain a compound 3; S3, carrying out a hydroxyl substitution on the compound 4 by adopting toluene sulfonyl chloride to obtain a compound 5, wherein the compound 4 has a structural formula as the follows; S4, carrying out a cyclization reaction on the compound 3 and the compound 5 to obtain a compound 6; S5, carrying out a formylation reaction on the compound 6 to obtain a compound 7; S6, carrying out a henry reaction on the compound 7 with nitromethane to obtain a compound 8; and S7, carrying out nitroso reduction reaction on the compound 8 to obtain the Na molecular fluorescent intermediate. The method is beneficial to improving the yield of the Na molecular fluorescentintermediate.

Fe molecular fluorescence testing agent and preparation method thereof

The invention provides a Fe molecular fluorescence testing agent and a preparation method thereof. The Fe molecular fluorescence testing agent has a structure represented by a formula (I). Theprovided Fe molecular fluorescence testing agent ta

Fe molecular-fluorescence testing fluid, preparation method thereof and application of Fe molecular-fluorescence testing fluid

The invention provides Fe molecular-fluorescence testing fluid, a preparation method thereof and application of the Fe molecular-fluorescence testing fluid. The Fe molecular-fluorescence testing fluid comprises a Fe molecular-fluorescence

A larene/ fragrant mixedsurrounds uncle butanol method for preparing ester compounds

The invention discloses a preparation method of an aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound. The preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound comprises the following steps of: firstly, under stirring condition, adding aromatic heterocycle borate compound or aromatic ring boric acid compound and di-tert-butyl dicarbonate ester into a solvent, and then adding a palladium catalyst and a ligand, so that a mixture A is obtained; secondly, heating the mixture A for carrying out reaction, and then cooling to room temperature, so that a mixture B is obtained; thirdly, diluting the mixture B with ethyl acetate, then filtering the diluted mixture B with diatomite, collecting filtrate, concentrating, and carrying out spin drying, so that the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is obtained. The preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound has the advantages that alkoxycarbonylation reaction on an aromatic heterocycle borate compound or aromatic ring boric acid compound is realized, and the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is directly generated; raw materials are non-toxic, inexpensive and available; a catalytic system is low in cost and has good stability and broad applicability; reaction conditions are mild, safety is high, and control is easy; a technology is simple, operation is easy, environmental friendliness is realized, and specificity is strong, so that the preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is applicable to industrialized production.

Active Site Mapping of Human CathepsinF with Dipeptide Nitrile Inhibitors

Cleavage of the invariant chain is the key event in the trafficking pathway of major histocompatibility complex classII. CathepsinS is the major processing enzyme of the invariant chain, but cathepsinF acts in macrophages as its functional synergist which is as potent as cathepsinS in invariant chain cleavage. Dedicated low-molecular-weight inhibitors for cathepsinF have not yet been developed. An active site mapping with 52 dipeptide nitriles, reacting as covalent-reversible inhibitors, was performed to draw structure-activity relationships for the non-primed binding region of human cathepsinF. In a stepwise process, new compounds with optimized fragment combinations were designed and synthesized. These dipeptide nitriles were evaluated on human cysteine cathepsinsF, B, L, K and S. Compounds 10 (N-(4-phenylbenzoyl)-leucylglycine nitrile) and 12 (N-(4-phenylbenzoyl)leucylmethionine nitrile) were found to be potent inhibitors of human cathepsinF, with Ki values 10nM. With all dipeptide nitriles from our study, a 3D activity landscape was generated to visualize structure-activity relationships for this series of cathepsinF inhibitors. Mapping with nitriles: For human cathepsinF, low-molecular-weight inhibitors have not been developed so far. Therefore, a library of 52 dipeptide nitriles, known to interact in a covalent but reversible manner with the active site cysteine, was evaluated for cathepsinF inhibition. With the kinetic data in hand, optimized candidates were designed, synthesized, and tested to improve the activity profile as cathepsinF inhibitors.

A mesoporous organosilica grafted Pd catalyst (MOG-Pd) for efficient base free and phosphine free synthesis of tertiary butyl esters via tertiary-butoxycarbonylation of boronic acid derivatives without using carbon monoxide

A mesoporous organosilica grafted palladium(ii) catalyst was synthesized and characterized using various spectroscopic techniques. Its catalytic activity was evaluated for the synthesis of tertiary butyl esters via tert-butoxycarbonylation of boronic acid

MATRIX METALLOPROTEINASE INHIBITORS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES

The present invention relates generally to bis-amide containing MMP inhibiting compounds, and more particularly to selectively deuterated bis-amide MMP-13 inhibiting compounds that exhibit increased stability or potency in relation to currently known MMP-

Preparation of tert-butyl esters via Pd-catalyzed tert-butoxycarbonylation of (hetero)aryl boronic acid derivatives

A novel protocol to synthesize tert-butyl esters from boronic acids or boronic acid pinacol esters and di-t-butyl dicarbonate has been successfully achieved. The cross-coupling reactions can produce up to 94% yields by using palladium acetate and triphenylphosphine as catalyst system, dioxane as a solvent. Moreover, a wide range of substrates including benzenes, pyridines, and quinolines boronic acids or boronic acid pinacol esters can fit with this system as well.

An efficient method for the preparation of tertiary esters by palladium-catalyzed alkoxycarbonylation of aryl bromides

The palladium-catalyzed alkoxycarbonylation of aryl bromides is described for the efficient preparation of tertiary esters. The protocol proved compatible with a wide variety of functionalized (hetero)aromatic bromides, as well as several different sterically hindered tertiary alcohols, affording the alkoxycarbonylated products in high yields. Finally, the formation of aromatic trityl esters is discussed.