1071-29-0

Upstream product

• 156-87-6 propan-1-ol-3-amine 

Downstream Products

• 109-55-7 1-amino-3-(dimethylamino)propane 
• 503-29-7 azetidine 

Relevant academic research and scientific papers

Synthesis of novel S-bridged heterotrinuclear complexes containing six-membered chelate rings: Structural, spectroscopic, and electrochemical properties of [Co{Rh(apt)3}2]3+ (apt = 3-aminopropanethiolate)

A bidentate ligand, 3-aminopropanethiolate (apt), was synthesized and treated with RhCl3·3H2O in basic water to yield a novel mononuclear complex, fac(S)-[Rh(apt)3] (1), which was characterized by spectroscopic methods. Furthermore, the reaction of 1 with CoCl2·6H2O in water formed the linear-type, S-bridged trinuclear complexes ΔΛ-[Co{Rh(apt)3} 2]3+ (2a) and ΔΔ/ΛΛ-[Co{Rh(apt) 3}2]3+ (2b), which were characterized by stereochemical, spectrochemical, and electrochemical methods. 2a and 2b are stable and exhibit trivalency in water. X-ray crystallographic analysis of 2a and 2b showed that all of the bridging sulfur atoms are fixed in the R configuration for the Δ unit and in the S configuration for the Λ unit, and each complex has six six-membered chelate rings, all of which are in the chair conformation. The crystal structure of the corresponding 2-aminoethanethiolate (aet) trinuclear complex ΔΛ-[Co{Rh(aet) 3}2]3+ (4a) was also determined. The structures of 2a and 2b have some differences from that of 4a as a result of the six-membered chelate rings. The Co...Rh distances in 2a and 2b [3.0490(4) and 3.063(1) A] are significantly longer than this distance in the aet complex 4a [2.9139(2) A]. The UV/Vis absorption spectra of 2a and 2b indicate a shift to higher energies as compared with 4a and ΔΔ/ ΛΛ-[Co{Rh(aet)3}2]3+ (4b). The chemical shifts for the NCH2 and SCH2 carbon atoms in 2a and 2b are shifted to higher fields than those for 4a and 4b in the NMR spectra. The CoIII/II redox potential values are -0.56 V (2a) and -0.57 V (2b) compared with -0.35 V (4a) and -0.36 V (4b). This shows that the Co III state is more stable in 2a and 2b than it is in 4a and 4b. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Direct and Asymmetric Nickel(II)-Catalyzed Construction of Carbon-Carbon Bonds from N-Acyl Thiazinanethiones

A wide array of new N-acyl thiazinanethiones are employed in a number of direct and enantioselective carbon-carbon-bond-forming reactions catalyzed by nickel(II) complexes. The electrophilic species are mostly prepared in situ from ortho esters, methyl et

N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE

The invention relates to compounds of formula (I), or a salt thereof wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ανβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

ISOFORM-SELECTIVE LYSINE DEACETYLASE INHIBITORS

Isoform-selective lysine deacetylase inhibitors are described. Inhibitors of the lysine deacetylase enzyme are useful as antitumor drugs and for treating addiction, asthma, cardio-vascular disease, immunosuppression, neurodegenerative diseases, sepsis, sickle-cell disease, uveal melanoma and termination of viral latency, particularly HIV-1 latency.

PROTEIN KINASE D INHIBITORS

Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and protein trafficking. Accordingly, pharmaceutically acceptable compositions of the inventive compounds are candidate therapeutics for pathological conditions conditioned by changes in PKD activity.