107147-53-5

Basic information

• Product Name: 1-(2-METHYLPHENYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
• Synonyms: IFLAB-BB F1912-0020;AKOS B029829;1-(2-METHYLPHENYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE;1-o-Tolyl-pyrimidine-2,4,6-trione;1-(o-tolyl)pyrimidine-2,4,6(1H,3H,5H)-trione
• CAS NO: 107147-53-5
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 218.21
• Mol File: 107147-53-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-METHYLPHENYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-METHYLPHENYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE(107147-53-5)
• EPA Substance Registry System: 1-(2-METHYLPHENYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE(107147-53-5)

Safety Data

• Hazardous Substances Data: 107147-53-5(Hazardous Substances Data)

Usage

General Description

1-(2-Methylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione is an organic chemical compound with the formula C11H8N2O3. It is a trione derivative, which is a class of compounds characterized by the presence of three carbonyl groups. 1-(2-METHYLPHENYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE is used in organic and pharmaceutical synthesis, and it has potential applications in the development of new drugs and materials. Its specific properties and potential uses depend on its molecular structure, reactivity, and biological activity, which can be further studied and optimized in research and development processes.

Upstream product

• 141-82-2 malonic acid 
• 614-77-7 N-(2-methylphenyl)urea 
• 108-59-8 malonic acid dimethyl ester 
• 105-53-3 diethyl malonate 
• 95-53-4 o-toluidine 

Downstream Products

• 929032-02-0 5,5-dibromo-1-o-tolylbarbituric acid 
• 185435-43-2 10-(4-tert-butylphenyl)-3-(2-methylphenyl)[5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione 
• 185435-34-1 6-(4-tert-butylanilino)-3-(2-methylphenyl)uracil 
• 142940-85-0 6-chloro-3-(2-methylphenyl)uracil 
• 143028-43-7 3-o-Tolyl-10-p-tolyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 143028-58-4 3-o-Tolyl-6-p-tolylamino-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Optimization of 5-arylidene barbiturates as potent, selective, reversible LSD1 inhibitors for the treatment of acute promyelocytic leukemia

Histone lysine specific demethylase 1 (LSD1) is overexpressed in diverse hematologic disorders and recognized as a promising target for blood medicines. In this study, molecular docking-based virtual screening united with bioevaluation was utilized to identify novel skeleton of 5-arylidene barbiturate as small-molecule inhibitors of LSD1. Among the synthesized derivatives, 12a exhibited reversible and potent inhibition (IC50 = 0.41 μM) and high selectivity over the MAO-A and MAO-B. Notably, 12a strongly induced differentiation effect on acute promyelocytic leukemia NB4 cell line and distinctly escalated the methylation level on histone 3 lysine 4 (H3K4). Our findings indicate that 5-arylidene barbiturate may represent a new skeleton of LSD1 inhibitors and 12a deserve as a promising agent for the further research.

Determination of energy barriers and racemization mechanisms for thermally interconvertable barbituric and thiobarbituric acid enantiomers

The enantiomers of the 5,5-dimethyl-1-(o-aryl)barbituric and 2-thiobarbituric acid derivatives have been separated by micropreparative liquid chromatography on the Chiralcel OD-H column. The activation barriers for the conversion of one enantiomer to its

Synthesis and reaction of novel 5-deazaflavins with axial chirality at pyrimidine ring moiety

A series of novel 5-deazaflavin derivatives possessing axial chirality at pyrimidine ring moiety have been prepared to investigate effects of the pyrimidine site on the stereoselective reactions between flavins and substrates. Successful optical resolutio