1071778-66-9

Basic information

• Product Name: N,N-dimethyl-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-6-quinolinamine
• CAS NO: 1071778-66-9
• Molecular Weight: 367.494
• Mol File: 1071778-66-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-6-quinolinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-6-quinolinamine(1071778-66-9)
• EPA Substance Registry System: N,N-dimethyl-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-6-quinolinamine(1071778-66-9)

Safety Data

• Hazardous Substances Data: 1071778-66-9(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 110-13-4 2,5-hexanedione 
• 13796-06-0 2-nitro-5-chlorobenzaldehyde dimethyl acetal 
• 83-24-9 2,5-dimethyl-1-phenyl-1H-pyrrole 
• 20423-24-9 2-amino-5-(dimethylamino)benzaldehyde 

Downstream Products

• 7187-62-4 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium 

Relevant articles and documents

New synthesis of pyrvinium that inhibits the β-catenin/Tcf4 pathway

A new and converged route is described for synthesis of pyrvinium, an anthelmintic and antitumor agent. This method uses easily obtained materials and simple and practical reactions, including the key Friedlaender condensation, to form the quinoline ring. The final product is generated through eight steps, with 23% yield and 96.6% purity (HPLC). This synthetic pyrvinium effectively inhibits β-catenin/Tcf4 driven TOP-luciferase activity, with an IC50 value 50 of 0.54 ± 0.06 μM.