20423-24-9

Upstream product

• 548798-23-8 5-(dimethylamino)-2-nitrobenzaldehyde 
• 13796-06-0 2-nitro-5-chlorobenzaldehyde dimethyl acetal 
• 395-81-3 5-fluoro-2-nitrobenzaldehyde 

Downstream Products

• 942614-41-7 2-(4-(N-(4-(dimethylamino)-2-formylphenyl)sulfamoyl)phenoxy)acetic acid ethyl ester 
• 1071778-66-9 N,N-dimethyl-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-6-quinolinamine 
• 7187-62-4 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium 
• 942614-43-9 2-(4-(N-(2-(1H-benzimidazol-2-yl)-4-(dimethylamino)phenyl)sulfamoyl)phenoxy)acetic acid ethyl ester 

Relevant academic research and scientific papers

New synthesis of pyrvinium that inhibits the β-catenin/Tcf4 pathway

A new and converged route is described for synthesis of pyrvinium, an anthelmintic and antitumor agent. This method uses easily obtained materials and simple and practical reactions, including the key Friedlaender condensation, to form the quinoline ring. The final product is generated through eight steps, with 23% yield and 96.6% purity (HPLC). This synthetic pyrvinium effectively inhibits β-catenin/Tcf4 driven TOP-luciferase activity, with an IC50 value 50 of 0.54 ± 0.06 μM.

Excited-state intramolecular proton transfer in 2-(2′- arylsulfonamidophenyl)benzimidazole derivatives: The effect of donor and acceptor substituents

(Chemical Equation Presented) A series of water-soluble 2-(2′-arylsulfonamidophenyl)benzimidazole derivatives containing electron-donating and accepting groups attached to various positions of the fluorophore π-system has been synthesized and characterize