1071964-53-8

Basic information

• Product Name: 1-(3-tert-butyl-1-(4-nitrophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea
• Synonyms: 1-(3-tert-butyl-1-(4-nitrophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea
• CAS NO: 1071964-53-8
• Molecular Weight: 562.626
• Mol File: 1071964-53-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(3-tert-butyl-1-(4-nitrophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-tert-butyl-1-(4-nitrophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea(1071964-53-8)
• EPA Substance Registry System: 1-(3-tert-butyl-1-(4-nitrophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea(1071964-53-8)

Safety Data

• Hazardous Substances Data: 1071964-53-8(Hazardous Substances Data)

Upstream product

• 1071964-93-6 C₁₅H₂₀N₂O₃ 
• 1202634-22-7 2,2,2-trichloroethyl (3-(tert-butyl)-1-(4-nitrophenyl)-1H-pyrazol-5-yl)carbamate 
• 251658-55-6 3-(tert-butyl)-1-(4-nitrophenyl)-1H-pyrazol-5-amine 
• 59997-51-2 trimethylacetylacetonitrile 
• 636-99-7 4-nitrophenylhydrazine hydrochloride 

Relevant articles and documents

Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-a agents that Target the p38 MAPK Pathway

A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-a production in lipopolysaccharide-stimulated THP-1 cells. The most active compound, 40g, inhibited TNF-a release with an IC50 value of 0.033 μM, which is equipotent to that of BIRB796 (IC50 = 0.032 μM).