107220-28-0

Basic information

• Product Name: Cevimeline Hydrochloride Salt
• Synonyms: CEVIMELINE, HYDROCHLORIDE SALT;Fks 508;Saligren;Snd 5008;cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine]hydrochloride;(2'R,3R)-rel-2'-Methyl- spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane] hydrochloride;SNK 508;CeviMelin
• CAS NO: 107220-28-0
• Molecular Formula: C10H18ClNOS
• Molecular Weight: 235.77402
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 107220-28-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 195-197?C
• Boiling Point: 308.5°Cat760mmHg
• Flash Point: 140.4°C
• Appearance: /
• Density: g/cm³
• Storage Temp.: Store at -20°C
• CAS DataBase Reference: Cevimeline Hydrochloride Salt(CAS DataBase Reference)
• NIST Chemistry Reference: Cevimeline Hydrochloride Salt(107220-28-0)
• EPA Substance Registry System: Cevimeline Hydrochloride Salt(107220-28-0)

Safety Data

• Hazardous Substances Data: 107220-28-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

A novel muscarinic M1 and M3 receptor agonist. Sialagogue.

Biological Activity

Selective M 1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC 50 values are 3.5 and 3 μ M respectively). Reverses AF64A-induced cognitive impairments in vivo .

Upstream product

• 107220-26-8 3-hydroxy-3-(mercaptomethyl)quinuclidine 
• 75-07-0 acetaldehyde 
• 107220-27-9 trans-cevimeline 
• 107220-27-9 2’-methylspiro{1-azabicyclo [2.2.2]octane-3,5'[1,3]oxathiolane} 
• 64168-68-9 Spiro- Hydrochlorid 
• 41353-91-7 1’-azaspiro[oxirane-2,3’-bicyclo[2.2.2]octane] 
• 1193-65-3 3-quinuclidinone hydrochloride 
• 1435450-21-7 C₉H₁₃NO₂S 
• 1435450-13-7 C₈H₁₄BrNO*BrH 
• 534-15-6 1,1-dimethoxyethane 
• 1067881-02-0 3-hydroxy-3-acetoxymercaptomethylquiniclidine thiolacetate 

Relevant articles and documents

A new route to cevimeline

The present work demonstrates a new route for the synthesis of cevimeline in which safe and odorless thiourea is utilized as a thiolating reagent.

OPHTHALMIC PERCUTANEOUSLY ABSORBED PREPARATION CONTAINING MUSCARINIC RECEPTOR AGONIST

A percutaneous absorption type ophthalmic preparation comprising muscarinic receptor agonist is prepared, which can promote lacrimal fluid secretion by administration to the skin surface of the eyelid, and which causes fewer side effects such as miosis, thereby to provide a percutaneous absorption type ophthalmic preparation capable of maintaining a therapeutically effective concentration of a muscarinic receptor agonist for promoting lacrimal fluid secretion, which is associated with fewer side effects such as miosis, and a method of promoting lacrimal fluid secretion by administering a percutaneous absorption type ophthalmic preparation containing a muscarinic receptor agonist to the skin surface of the eyelid.