534-15-6 Usage
Description
1,1-Dimethoxyethane is an aliphatic hydrocarbon which is found in figs, leek, and black tea. It gives a sharp ethereal, fruity and green note. It is used as a flavoring agent in food. 1,1-Dimethoxyethane is also used as a reagent for the diol protection and condensation reactions.
Preparation
Different sources of media describe the Preparation of 534-15-6 differently. You can refer to the following data:
1. To a flask equipped with a mechanical stirrer, condenser, and gas addition tube and containing 10 gm of a 6 3% solution of boron trifluoride in methanol is added 1.0 gm of mercuric oxide and 200 gm (6.25 moles) of methanol. Then 70 gm (3.13 moles) of acetylene is added with vigorous stirring at room temperature. After the reaction the catalyst is neutralized with aqueous potassium carbonate, the product is extracted into ether, dried, and distilled to afford 104 gm (37%), b.p. 64°-65°C.
2. From acetaldehyde and methanol.
Reference
Evaluation of Certain Food Additives and Contaminants: Fifty-seventh report of the Joint FAO/WHO Expert Committee on Food Additives, 2001, ISBN 92-4-120909-7
M. J. Taschner, Encyclopedia of Reagents for Organic Synthesis, 2001, ISBN 9780471936237
Chemical Properties
Different sources of media describe the Chemical Properties of 534-15-6 differently. You can refer to the following data:
1. clear colorless liquid
2. 1,1-Dimethoxybenzene has a sharp, sweet, alcohol, ether, green, new-mown-hay odor
Occurrence
Reported found in raspberry, blackberry, strawberry, peas, fresh figs, hop oil, coffee, cognac, white wine
and tea.
Uses
Different sources of media describe the Uses of 534-15-6 differently. You can refer to the following data:
1. 1,1-Dimethoxyethane is used as a reagent in the synthesis of tricyclic and tetracyclic 1,5-benzodiazepine derivatives as nevirapine analogues.
2. Acetaldehyde dimethyl acetal may be used in the preparation of glucoside derivatives of steganol. It may be used as polymer solvent for the encapsulation of water-soluble model protein, bovine serum albumin into biodegradable poly(D,L-lactic acid.
3. As Mering's mixture which is 2 vol dimethylacetal and 1 vol chloroform.
General Description
A liquid with a sharp odor. Less dense than water. Flash point between 0-73°F. Mildly toxic by ingestion and inhalation. Severely irritates the skin and eyes. Used to make other chemicals.
Air & Water Reactions
Highly flammable. May form unstable peroxides when exposed to oxygen. These products can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Slightly soluble in water.
Reactivity Profile
1,1-Dimethoxyethane may react violently with strong oxidizing agents. Can act as a weak base to form salts with strong acids and addition complexes with Lewis acids. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
Health Hazard
Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Mildly toxic by
inhalation, ingestion, and skin contact. A
skin and eye irritant. A very dangerous fire
hazard when exposed to heat, flame, or
oxiduzers. When exposed to heat or flame it
can react vigorously with oxidizing
materials. To fight fire, use foam, CO2, dry
chemical. When heated to decomposition it
emits acrid smoke and irritating fumes. See
also GLYCOL ETHERS.
Purification Methods
Distil the dimethyl acetal through a fractionating column and fraction boiling at 63.8o/751mm is collected. It forms an azeotrope with MeOH. Alternatively purify it as for acetal above. It has been purified by GLC. [Beilstein 1 IV 3103.]
Check Digit Verification of cas no
The CAS Registry Mumber 534-15-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 534-15:
(5*5)+(4*3)+(3*4)+(2*1)+(1*5)=56
56 % 10 = 6
So 534-15-6 is a valid CAS Registry Number.
534-15-6Relevant articles and documents
Kinetics and Mechanistic Study of the Methanol Homologation with Cobalt-Ruthenium mixed Catalyst
Watanabe, Kazuhiro,Kudo, Kiyoshi,Sugita, Nobuyuki
, p. 2029 - 2037 (1985)
The role of each catalyst was examined in detail in the methanol homologation with cobalt-ruthenium miwed catalyst.Cobalt catalyst showed much higher activity for the hydrocarbonylation of methanol than ruthenium.On the other hand, the hydrogenation of acetaldehyde proceeded much more rapidly by ruthenium catalyst.The rate of methanol homologation in 1,4-dioxane with cobalt-ruthenium mixed catalyst system was found to be of the first order with respect to the partial pressure of CO.The in situ IR spectra indicated that (1-) was an active species for the hydrocarbonylation of methanol and that existed under the reaction conditions.On the basis of both the kinetic studies and in situ IR spectral observations, the reaction mechanism of methanol homologation was fully discussed.
High activity cobalt based catalysts for the carbonylation of methanol
Marr, Andrew C.,Ditzel, Evert J.,Benyei, Attila C.,Lightfoot,Cole-Hamilton, David J.
, p. 1379 - 1380 (1999)
[Cp(*)Co(CO)2] in the presence of PEt3 and Mel catalyses the carbonylation of methanol with initial rates up to 44 mol dm-3 h-1 before decaying to a second catalytic phase with rates of 3 mol dm-3 h-1; [CoI(CO)2(PEt3)2], which is trigonal bipyramidal with axial PEt3 ligands, has been isolated from the final reaction solution.
-
Swann,Howard,Reid
, p. 1277 (1931)
-
Functional methacryloyoxy acetals: II. Electophilic addition of alcohols to vinyloxyalkyl methacrylates
Gorelova,Oparina,Parshina,Gusarova,Trofimov
, p. 1683 - 1687 (2001)
Alcohols of various structures, in particular, ethylene, acetylene, fluorocontaining alcohols, add regio-and chemoselectively to the vinyloxy group of vinyloxyalkyl methacrylates at 20-40°C in the presence of catalytic quantities of trifluoroacetic acid a
Tetrachloromethane Hydrodechlorination over Palladium-Containing Nanodiamonds
Belkina, E. G.,Gruzdev, M. S.,Kalmykov, P. A.,Klyuev, M. V.,Lysenok, A. A.,Magdalinova, N. A.
, p. 1148 - 1153 (2020/10/14)
Abstract: Using nanodiamonds of the UDD-STP brand 1 wt % palladium-containing nanodiamonds are obtained and tested as catalysts of tetrachloromethane hydrodechlorination under mild conditions (solvents, ethanol and methanol; Т = 298–318 K; PH2 = 0.1 MPa). The catalytic properties of the obtained material and a palladium-containing analog based on activated carbon are compared. It is shown that the hydrodechlorination reaction occurs in a stepwise manner via two pathways: to form products with a smaller content of chlorine, for example, chloroform, and to yield oxygen-containing products, for example, diethyl carbonate. The qualitative and quantitative compositions of reaction products are determined by gas chromatography/mass spectrometry.
A catalytic conversion method for preparing pyruvate ester of lactic acid (by machine translation)
-
Paragraph 0017, (2016/10/10)
A method for preparing pyruvate through catalytic conversion of lactic acid is provided; according to the method, with oxygen or air as an oxidant, alcohol as a solvent, and molybdovanadophosphoric heteropoly acid and/or tungstovanadophosphoric heteropoly acid as a catalyst, and by coupling of a catalytic oxidation reaction and an esterification reaction, lactic acid is converted into pyruvate by one step. The method directly adopts oxygen or air as the oxidant and is green and safe; the used raw material lactic acid is obtained directly from conversion of biomass resources, moreover, the reaction conditions are mild, and the method has important application prospects.
