107236-27-1

Usage

Chemical Family

1H-Indole, 1-(2-chloro-1-oxopropyl)-2,3-dihydro(9CI) belongs to the indole family.

Derivative

It is a derivative of 1H-indole.

Structural Motif

It features a 2-chloro-1-oxopropyl group at the 1-position.

Moiety

It has a 2,3-dihydro moiety.

Potential Applications

It may have potential applications in medicinal chemistry.

Biological Activity

The specific properties and uses depend on its chemical and biological activities.

Drug Lead

It may have potential as a drug lead.

Research Tool

It may serve as a research tool.

Further Research

Further research and investigation are needed to fully understand its potential in various applications.

Upstream product

• 496-15-1 1-indoline 
• 7623-09-8 2-chloropropionyl chloride 
• 1297604-93-3 2-(triphenylphosphoranylideneamino)phenethyl 2-chloropropanoate 

Downstream Products

• 1239488-10-8 (S)-1-(indolin-1-yl)-2-phenylpropan-1-one 
• 1239488-19-7 (R)-1-(indolin-1-yl)-2-phenylpropan-1-one 
• 1256601-32-7 2-chloro-1-(indolin-1-yl)propan-1-one 
• 1256601-02-1 2-chloro-1-(indolin-1-yl)propan-1-one 

Relevant academic research and scientific papers

Unexpected synthesis of N-Acyl indolines via a consecutive cyclization of iminophosphorane

N-Acyl indolines were obtained unexpectedly from a consecutive cyclization of iminophosphorane in refluxing xylene or 1,2-dichlorobenzene in good yields. This new approach provides an efficient and direct access to the biologically important indolines which are further oxidizable to indoles and oxindoles. Georg Thieme Verlag Stuttgart.

Asymmetric suzuki cross-couplings of activated secondary alkyl electrophiles: Arylations of racemic α-chloroamides

A nickel-catalyzed stereoconvergent method for the enantioselective Suzuki arylation of racemic α-chloroamides has been developed. This process provides a unique example of an asymmetric arylation of an α-haloamide, an enantioselective arylation of an α-chlorocarbonyl compound, and an asymmetric Suzuki reaction with an activated alkyl electrophile or an arylboron reagent. The method is also applicable to the corresponding enantioselective cross-coupling of α-bromoamides. The coupling products can be transformed without racemization into enantioenriched α-arylcarboxylic acids and primary alcohols. A modest kinetic resolution of the α-chloroamide was observed; a mechanistic study indicated that the selectivity may reflect discrimination by the chiral catalyst of the two enantiomeric α-chloroamides in an irreversible oxidative-addition process.

Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure-activity relationships

Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 2n and 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 7b. Their related synthesis was also reported.