1256601-02-1

Basic information

• Product Name: 2-chloro-1-(indolin-1-yl)propan-1-one
• CAS NO: 1256601-02-1
• Molecular Weight: 209.675
• Mol File: 1256601-02-1.mol

Chemical Properties

• CAS DataBase Reference: 2-chloro-1-(indolin-1-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-1-(indolin-1-yl)propan-1-one(1256601-02-1)
• EPA Substance Registry System: 2-chloro-1-(indolin-1-yl)propan-1-one(1256601-02-1)

Safety Data

• Hazardous Substances Data: 1256601-02-1(Hazardous Substances Data)

Upstream product

• 23418-91-9 9-phenyl-9-borabicyclo[3.3.1]nonane 
• 107236-27-1 2-chloro-1-(indolin-1-yl)propan-1-one 

Downstream Products

• 1239488-19-7 (R)-1-(indolin-1-yl)-2-phenylpropan-1-one 
• 1239488-10-8 (S)-1-(indolin-1-yl)-2-phenylpropan-1-one 

Relevant articles and documents

Asymmetric suzuki cross-couplings of activated secondary alkyl electrophiles: Arylations of racemic α-chloroamides

A nickel-catalyzed stereoconvergent method for the enantioselective Suzuki arylation of racemic α-chloroamides has been developed. This process provides a unique example of an asymmetric arylation of an α-haloamide, an enantioselective arylation of an α-chlorocarbonyl compound, and an asymmetric Suzuki reaction with an activated alkyl electrophile or an arylboron reagent. The method is also applicable to the corresponding enantioselective cross-coupling of α-bromoamides. The coupling products can be transformed without racemization into enantioenriched α-arylcarboxylic acids and primary alcohols. A modest kinetic resolution of the α-chloroamide was observed; a mechanistic study indicated that the selectivity may reflect discrimination by the chiral catalyst of the two enantiomeric α-chloroamides in an irreversible oxidative-addition process.