107267-41-4

Upstream product

• 119-59-5 4,4'-sulfinyldianiline 
• 143-33-9 sodium cyanide 
• 46836-99-1 bis(4-cyanophenyl)sulfide 
• 139-65-1 4,4'-thiobisaniline 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 875843-17-7 4,4'-sulfinyl-bis-benzamidine 
• 81755-10-4 4-[18F]fluorobenzonitrile 
• 1591-30-6 (1,1'-biphenyl)-4,4'-dicarbonitrile 
• 2920-38-9 4-cyano-1,1'-biphenyl 

Relevant academic research and scientific papers

Selective oxidation of sulfides to sulfoxides with cyanuric chloride and urea-hydrogen peroxide adduct

Although a number of methods have been developed for the selective oxidation of sulfides to sulfoxides, the need remains for alternative efficient, reliable strategies that can be generally applied to various sulfides and that use readily available reagents under mild reaction conditions. Herein, we report the use of urea-hydrogen peroxide adduct (UHP) and cyanuric chloride in CH 3CN at room temperature to convert sulfides to sulfoxides in excellent yields. In particular, this protocol produced sulfoxides with aromatic rings bearing electron-withdrawing groups in excellent yields.

Desulfurization of Diaryl(heteroaryl) Sulfoxides with Benzyne

Two benzyne-enabled desulfurization reactions have been demonstrated which convert diaryl sulfoxides and heteroaryl sulfoxides to biaryls and desulfurized heteroarenes, respectively. The reaction accessing biaryls tolerates a variety of functional groups, such as halides, pseudohalides, and carbonyls. Mechanistic studies reveal that both reactions proceed via a common assembly process but divergent disassemblies of the generated tetraaryl(heteroaryl) sulfuranes.

No-carrier-added [18F]fluoroarenes from the radiofluorination of diaryl sulfoxides

No-carrier-added [18F]fluoroarenes were synthesized through the radiofluorination of diaryl sulfoxides with [18F]fluoride ion. Diaryl sulfoxides bearing a para electron-withdrawing substituent readily gave the corresponding 4-[18F]fluoroarenes in high RCYs. This process broadens the scope for preparing novel 18F-labeling synthons and PET radiotracers.

PHASE TRANSFER CONTROLLED SELECTIVE OXIDATION OF DIARYLSULFIDES TO DIARYLSULFOXIDES USING POTASSIUM HYDROGEN PERSULFATE

The use of biphasic reaction conditions and a phase transfer catalyst controls the oxidation reaction of potassium hydrogen persulfate with diarylsulfides yielding predominantly sulfoxides.This is in contrast to the raction in polar solvents where sulfones are the major products.