107304-64-3

Usage

Uses

Used in Pharmaceutical Industry:
3-beta-Hydroxy-olean-12-en-28-oic acid propionate is used as a pharmaceutical agent for its potential in treating various diseases, including cancer and inflammatory disorders. Its unique chemical structure and biological activities contribute to its potential as a new therapeutic option.
Used in Cancer Treatment:
3-beta-Hydroxy-olean-12-en-28-oic acid propionate is used as an anticancer agent for its ability to inhibit the growth of cancer cells. It has shown promise in research for its potential to be developed into a new treatment option for various types of cancer.
Used in Anti-Inflammatory Applications:
3-beta-Hydroxy-olean-12-en-28-oic acid propionate is used as an anti-inflammatory agent for its ability to reduce inflammation in the body. Its potential in treating inflammatory disorders makes it a valuable compound for further research and development in this area.

InChI:InChI=1/C33H52O4/c1-9-26(34)37-25-13-14-30(6)23(29(25,4)5)12-15-32(8)24(30)11-10-21-22-20-28(2,3)16-18-33(22,27(35)36)19-17-31(21,32)7/h10,22-25H,9,11-20H2,1-8H3,(H,35,36)/t22-,23-,24+,25-,30-,31+,32+,33-/m0/s1

Upstream product

• 508-02-1 Oleanolic acid 
• 123-62-6 propionic acid anhydride 

Relevant academic research and scientific papers

Oleanolic acid-miazines conjugate and its preparation method and application

The invention discloses an oleanolic acid-pyrimidine conjugate and a preparation method thereof as well as application of the oleanolic acid-pyrimidine conjugate in the pharmaceutical field. An applicant finds that the anti-tumor activity of the oleanolic acid-pyrimidine conjugate is higher than that of a parent body namely oleanolic acid, and a lead compound is provided for developing new anti-tumor medicaments. The conjugate has a structure as shown in the following general formula (I), (II) or (III).

Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents

A broad set of potential bioactive conjugate compounds has been semi-synthesized through solution- and solid-phase organic procedures, coupling two natural pentacyclic triterpene acids, oleanolic (OA) and maslinic acids (MA), at the hydroxyl groups of the A-ring of the triterpene skeleton, with 10 different acyl groups. These acyl OA and MA derivatives have been tested for their anti-proliferative (against the b16f10 murine melanoma cancer cells) and antiviral (as inhibitors of the HIV-1-protease) effects. Several derivatives have shown high levels of early and total apoptosis (up to 90%). Most of the compounds that exhibited anti-proliferative effects also generated ROS, probably involving the activation of an intrinsic apoptotic route. The only four compounds that did not cause the release of ROS could be related to the participation of a probable extrinsic activation of the apoptosis mechanism. A great number of these acyl OA and MA derivatives have proved to be potent inhibitors of the HIV-1-protease, the most active inhibitors having IC 50 values between 0.31 and 15.6 μM, these values being between 4 and 186 times lower than their non-acylated precursors. The potent activities exhibited in the apoptosis-activation processes and in the inhibition of the HIV-1-protease by some OA and MA acylated derivatives imply that these compounds could be used as new, safe, and effective anticancer and/or antiviral drugs.