1073153-79-3

Upstream product

• 914654-75-4 1-(1,1-dimethylethyl) 4-piperidinedicarboxylate anhydride with 1H-imidazole-1-carboxylic acid 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 

Downstream Products

• 1073153-81-7 C₁₉H₂₃FN₂O₃ 
• 1073153-82-8 C₁₉H₂₃FN₂O₃ 
• 1616235-40-5 tert-butyl 4-(4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperidine-1-carboxylate 
• 1616235-41-6 tert-butyl 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

PYRAZOLE SUBSTITUTED IMIDAZOPYRAZINES AS CASEIN KINASE 1 D/E INHIBITORS

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent Melanin-Concentrating Hormone Receptor 1 (MCH-R1) antagonists

A series of 1,3-disubstituted-1H-pyrrole-based antagonists of the human Melanin-Concentrating Hormone Receptor 1 (h-MCH-R1) are reported. High-throughput screening of the AstraZeneca compound collection yielded 1, a hit with moderate affinity towards MCH-