1073616-24-6

Basic information

• Product Name: (S)-3-chloro-5-(1,2-dihydroxyethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide
• Synonyms: (S)-3-chloro-5-(1,2-dihydroxyethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide
• CAS NO: 1073616-24-6
• Molecular Weight: 441.837
• Mol File: 1073616-24-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-chloro-5-(1,2-dihydroxyethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-chloro-5-(1,2-dihydroxyethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide(1073616-24-6)
• EPA Substance Registry System: (S)-3-chloro-5-(1,2-dihydroxyethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide(1073616-24-6)

Safety Data

• Hazardous Substances Data: 1073616-24-6(Hazardous Substances Data)

Upstream product

• 1073617-86-3 (S)-1-(3-chloro-1',2',3',6'-tetrahydro-[2,4']bipyridinyl-5-yl)ethane-1,2-diol 
• 1548-13-6 p-trifluoromethyl-phenylisocyanate 
• 71690-05-6 5,6-dichloro-pyridine-3-carbaldehyde 
• 1001193-62-9 2,3-dichloro-5-vinylpyridine 
• 1073617-83-0 (S)-1-(5,6-dichloropyridin-3-yl)ethane-1,2-diol 
• 1073617-85-2 (S)-3-chloro-5-(1,2-dihydroxyethyl)-3',6'-dihydro-2'H-[2,4']-bipyridinyl-1'-carboxylic acid tert-butyl ester 
• 683243-82-5 (1S,1R)-1-(5,6-dichloro-pyridin-3-yl)-ethanol 
• 162327-73-3 5,6-dichloro-N-methoxy-N-methyl-3-pyridinecarboxamide 
• 54127-30-9 5,6-dichloro-3-pyridinemethanol 
• 54127-29-6 5,6-dichloronicotinoyl chloride 
• 41667-95-2 5,6-dichloronicotinic acid 
• 120800-05-7 2,3-dichloro-5-acetylpyridine 

Relevant articles and documents

Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1 S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3, 6-dihydro-2 H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management

A series of novel tetrahydropyridinecarboxamide TRPV1 antagonists were prepared and evaluated in an effort to optimize properties of previously described lead compounds from piperazinecarboxamide series. The compounds were evaluated for their ability to block capsaicin and acid-induced calcium influx in CHO cells expressing human TRPV1. The most potent of these TRPV1 antagonists were further characterized in pharmacokinetic, efficacy, and body temperature studies. On the basis of its pharmacokinetic, in vivo efficacy, safety, and toxicological properties, compound 37 was selected for further evaluation in human clinical trials.