71690-05-6

Basic information

• Product Name: 2,3-DICHLORO-5-FORMYLPYRIDINE
• Synonyms: 2,3-DICHLORO-5-FORMYLPYRIDINE;5,6-DICHLOROPYRIDINE-3-CARBALDEHYDE;5,6-Dichloropyridine-3-carboxaldehyde;5,6-Dichloro-3-pyridinecarboxaldehyde;5,6-Dichloropyridyl-3-carboxaldehyde
• CAS NO: 71690-05-6
• Molecular Formula: C₆H₃Cl₂NO
• Molecular Weight: 176
• Product Categories: Pyridine;Boronic Acid;Heterocycle-Pyridine series
• Mol File: 71690-05-6.mol

Chemical Properties

• Boiling Point: 268.604 °C at 760 mmHg
• Flash Point: 116.248 °C
• Appearance: /
• Density: 1.489 g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2,3-DICHLORO-5-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DICHLORO-5-FORMYLPYRIDINE(71690-05-6)
• EPA Substance Registry System: 2,3-DICHLORO-5-FORMYLPYRIDINE(71690-05-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 71690-05-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-DICHLORO-5-FORMYLPYRIDINE is used as a key intermediate in the synthesis of [(pyridyl)piperazinyl]benzimidazoles analogs. These analogs are potent, orally available antagonists of the transient receptor potential vanilloid 1 (TRPV1) and serve as analgesics, providing pain relief through the modulation of pain signaling pathways.
Used in Agrochemical Industry:
2,3-DICHLORO-5-FORMYLPYRIDINE is also utilized in the synthesis of heterocyclic aryl isoxazolines, which exhibit insecticidal activities. These compounds are valuable in the development of novel insecticides, offering effective pest control solutions in agriculture and other industries.

InChI:InChI=1/C6H3Cl2NO/c7-5-1-4(3-10)2-9-6(5)8/h1-3H

Upstream product

• 54127-29-6 5,6-dichloronicotinoyl chloride 
• 162327-73-3 5,6-dichloro-N-methoxy-N-methyl-3-pyridinecarboxamide 
• 68-12-2 N,N-dimethyl-formamide 
• 54127-30-9 5,6-dichloro-3-pyridinemethanol 
• 41667-95-2 5,6-dichloronicotinic acid 

Downstream Products

• 1073616-24-6 (S)-3-chloro-5-(1,2-dihydroxyethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide 
• 1073617-14-7 (R)-3-chloro-5-(1,2-dihydroxyethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide 
• 1073616-37-1 (S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide 
• 1073616-26-8 (S)-3-chloro-5-(1,2-dihydroxyethyl)-3',6'-dihydro-2'H-[2,4']bipyridinyl-1'-carboxylic acid (3-chloro-4-trifluoromethylphenyl)amide 
• 1073616-33-7 (S)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)-N-(4-trifluoromethoxyphenyl)piperazine-1-carboxamide 
• 1073616-35-9 (S)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)piperazine-1-carboxamide 
• 1073616-38-2 4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide 
• 1073616-41-7 3-chloro-5-(methylsulfonamidomethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide 
• 1073616-32-6 (S)-N-(4-tert-butylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide 
• 71690-06-7 2,3-dichloro-5-(difluoromethyl)pyridine 
• 943137-86-8 3-(5-chloro-6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole 
• 950482-85-6 5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole 
• 1308279-71-1 ethyl (E)-3-{2-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chloro-5-pyridinyl}-2-propenoate 
• 1308279-77-7 ethyl (E)-3-{2-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-chloro-5-pyridinyl}-2-propenoate 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDINE COMPOUNDS AND INTERMEDIATES THEREOF

The present invention discloses a process for the preparation of substituted pyridine compounds of formula (I), comprises a step in which vinylogous nitriles of formula (II), are obtained from substituted α,β-unsaturated nitrile compounds of formula (III), and a further step of converting the vinylogous nitrile compounds of formula (II) into substituted pyridines of formula (I); wherein R1, R2, R3, R4 and LG are as defined in the description.

A “universal” catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides

Functionalized (hetero)aromatic compounds are indispensable chemicals widely used in basic and applied sciences. Among these, especially aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides represent valuable fine and bulk chemicals, which are used in chemical, pharmaceutical, agrochemical, and material industries. For their synthesis, catalytic aerobic oxidation of alcohols constitutes a green, sustainable, and cost-effective process, which should ideally make use of active and selective 3D metals. Here, we report the preparation of graphitic layers encapsulated in Co-nanoparticles by pyrolysis of cobalt-piperazine-tartaric acid complex on carbon as a most general oxidation catalyst. This unique material allows for the synthesis of simple, functionalized, and structurally diverse (hetero)aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides from alcohols in excellent yields in the presence of air.

BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS

The present invention discloses compounds of Formula (I), or pharmaceuticall acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising th

Method for preparing aldehyde and acid by electrochemical dehydrochlorination of polychloromethylpyridine derivatives

The invention discloses a method for preparing aldehyde and an acid by electrochemical dechlorination of a polychloromethylpyridine derivative, the method comprises the following steps: dissolving thepolychloromethylpyridine derivative in an acetic acid and acetate- containing buffer solution to obtain an electrolytic reaction solution; taking the electrolytic reaction solution as a cathode liquid, performing electrolytic reduction dechlorination reaction at a cathode, and hydrolyzing in the solution to obtain a polychlorinated pyridylaldehyde or acid derivative. The polychloromethylpyridinederivative is shown in formula (I), and the product polychlorinated pyridylaldehyde or acid derivative is shown in formula (II): in the formula (I), m is 0, 1, 2, 3 or 4, n is 0 or 1, and R' is an easy-to-oxidize or easy-to-hydrolyze substituent. The m and the R' in the formula (II) are same as that in the formula (I), R is H or OH, no waste acid is generated in the preparation process, the easy-to-oxidize or easy-to-hydrolyze substituent contained in the polychloromethylpyridine derivative and carbon-chlorine bonds on pyridine rings are not affected, and the recovery conversion rate is high.

HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES

The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Heterocyclic compounds

The invention relates to compounds of Formula I: wherein Ar1, Ar2, Ar3, L1, L2, Y, Z and v are defined in the specification, and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof.

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for prepa

Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4- hydroxyphenyl]-3-chlorocinnamic acid

(E)-4-[3'-(1-Adamantyl)-4'-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell cycle arrest and apoptosis of cancer cells. Because its pharmacologic properties-solubility, bioavailability, and toxicity-required improvement for translation, s

MONOCYCLIC COMPOUNDS AND THEIR USE AS TRPV1 LIGANDS

The invention relates to compounds of formula I and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof.