107367-69-1Relevant academic research and scientific papers
Radical C-H Arylation of Oxazoles with Aryl Iodides: Dppf as an Electron-Transfer Mediator for Cs2CO3
Guo, Zhengwei,Li, Man,Mou, Xue-Qing,He, Gang,Xue, Xiao-Song,Chen, Gong
, p. 1684 - 1687 (2018)
A radical C-H arylation reaction of oxazoles with (hetero)aryl iodides using Cs2CO3 as base/electron donor and 1,1′-bis(diphenylphosphino) ferrocene (dppf) as a catalytic SET mediator is reported. The overall reaction likely follows the general base-promoted homolytic aromatic substitution mechanism through a radical-chain pathway. DFT calculations suggest that dppf forms a complex with CsCO3-, enhancing its SET reducing ability to generate an aryl radical from ArI.
A synthetic approach to the phorboxazoles – Synthesis of the C20–C32 central core
Leahy, James W.,Boyer, Stephen J.
, p. 3238 - 3241 (2017)
An enantiospecific synthesis of the C20–C32 central core of the phorboxazole scaffold, including the non-macrocyclic oxazole is detailed in 17 steps (longest linear sequence) from methacrolein in 7.8% overall yield. All of the stereocenters are communicated from a single Evans aldol reaction, and the final compound is suitably functionalized for further elaboration to the natural products.
Synthesis of 2,4- and 2,4,5-substituted oxazoles via a silver triflate mediated cyclization
Bailey, Jessica L.,Sudini, Ravinder R.
, p. 3674 - 3677 (2014/06/23)
2,4- and 2,4,5-substituted oxazoles were prepared from a broad range of bromo-ketones and amides in high yield and purity.
