181633-60-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-formyloxazole-4-carboxylate is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and enhance the properties of existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, Ethyl 2-formyloxazole-4-carboxylate is utilized as an intermediate in the production of agrochemicals, playing a role in the creation of effective and innovative products for agricultural applications.
Used in Organic Synthesis:
Ethyl 2-formyloxazole-4-carboxylate is employed as a building block in the synthesis of other organic compounds, contributing to the advancement of organic chemistry and the development of new materials and substances with diverse applications.

Upstream product

• 70-23-5 ethyl Bromopyruvate 
• 107367-69-1 C₁₄H₁₃NO₃ 
• 132629-37-9 ethyl 2-[(E)-2-phenylethenyl]oxazole-4-carboxylate 
• 181633-66-9 2-(1,2-Dihydroxy-2-phenyl-ethyl)-oxazole-4-carboxylic acid ethyl ester 

Downstream Products

• 617705-26-7 2-ethynyloxazole-4-carboxylic acid ethyl ester 
• 603999-34-4 C₂₇H₂₇F₃N₄O₆ 
• 224578-16-9 2-(4-Methoxy-benzyloxymethyl)-oxazole-4-carbaldehyde 
• 181633-69-2 2'-Methoxymethoxymethyl-[2,4']bioxazolyl-4-carboxylic acid [(1R,2R)-1-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-amide 
• 181633-64-7 2'-Methoxymethoxymethyl-[2,4']bioxazolyl-4-carboxylic acid [(1R,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-2-methyl-propyl]-amide 
• 1026522-61-1 2'-Methoxymethoxymethyl-[2,4']bioxazolyl-4-carboxylic acid [(1R,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-formyl-2-methyl-propyl]-amide 
• 617705-31-4 2-{(E)-4-[(1S,2S)-2-(4-Methoxy-benzyloxymethyl)-cyclopropyl]-but-3-en-1-ynyl}-oxazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

A synthetic approach to the phorboxazoles – Synthesis of the C20–C32 central core

An enantiospecific synthesis of the C20–C32 central core of the phorboxazole scaffold, including the non-macrocyclic oxazole is detailed in 17 steps (longest linear sequence) from methacrolein in 7.8% overall yield. All of the stereocenters are communicated from a single Evans aldol reaction, and the final compound is suitably functionalized for further elaboration to the natural products.

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES

The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula (I), and the variable R1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

FLUORINATED AMINOTRIAZOLE DERIVATIVES

The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS

The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. The compounds are useful for the prevention or treatment of diseases, which respond to the modulation of the ALX receptor such as inflammatory diseases.

Toward the total synthesis of disorazole A1: Asymmetric synthesis of the masked northern half

The stereoselective synthesis of the masked northern half of the antimitotic natural product disorazole A1 is described involving as key step a Z-selective Wittig olefination of a C1-C11 epoxy aldehyde with a C12-C19 phosphonium iodide.