107381-35-1 Usage
Uses
Used in Cardiology:
(R)-(+)-Propafenone hydrochloride is used as an antiarrhythmic agent for treating atrial fibrillation and atrial flutter, which are common types of irregular heartbeats. It helps in stabilizing the heart's rhythm and preventing the recurrence of these conditions.
Additionally, (R)-(+)-Propafenone hydrochloride is used as a preventive measure for paroxysmal supraventricular tachycardia, a rapid and irregular heart rate that originates in the upper chambers of the heart.
Although not a first-line treatment, (R)-(+)-Propafenone hydrochloride may be prescribed when other medications have proven ineffective or are unsuitable for a patient, making it an essential alternative in the management of cardiac arrhythmias.
Check Digit Verification of cas no
The CAS Registry Mumber 107381-35-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,3,8 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 107381-35:
(8*1)+(7*0)+(6*7)+(5*3)+(4*8)+(3*1)+(2*3)+(1*5)=111
111 % 10 = 1
So 107381-35-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H/t18-;/m1./s1
107381-35-1Relevant academic research and scientific papers
Improved Synthesis of the Enantiomers of Propafenone Using Chiral Building Blocks
Ecker,Noe,Fleischhacker
, p. 53 - 59 (2007/10/03)
A short and efficient synthesis of the enantiomers of the antiarrhythmic drug propafenone (1) is described using both (R)-isopropylideneglycerol tosylate and (S)-glycidyl tosylate as chiral building blocks. The key step of the high yield synthesis is the
A method for the synthesis of the enantiomers of propafenone
Ecker,Fleischhacker,Noe
, p. 691 - 695 (2007/10/02)
The enantiomers of the antiarrhythmic drug propafenone were synthesized using a recoverable acetal protective group. The key-step in the synthesis was the protection of the cyanohydrin 7 with enantiomerically pure MBF-lactol, which allows not only easy se
