107381-36-2

Usage

Uses

Used in Pharmaceutical Industry:
(S)-(-)-Propafenone hydrochloride is used as an antiarrhythmic agent for treating irregular heartbeats and atrial fibrillation. It helps maintain a regular heart rhythm by affecting the electrical activity in the heart, making it a valuable component in the management of certain heart conditions.
Used in Cardiology:
In the field of cardiology, (S)-(-)-Propafenone hydrochloride is utilized as a class Ic antiarrhythmic drug to regulate heart rhythm disorders. It is often prescribed in combination with other medications to provide comprehensive treatment for specific heart conditions, enhancing the overall effectiveness of the treatment plan.

InChI:InChI=1/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H/t18-;/m0./s1

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Relevant academic research and scientific papers

Improved Synthesis of the Enantiomers of Propafenone Using Chiral Building Blocks

A short and efficient synthesis of the enantiomers of the antiarrhythmic drug propafenone (1) is described using both (R)-isopropylideneglycerol tosylate and (S)-glycidyl tosylate as chiral building blocks. The key step of the high yield synthesis is the

A method for the synthesis of the enantiomers of propafenone

The enantiomers of the antiarrhythmic drug propafenone were synthesized using a recoverable acetal protective group. The key-step in the synthesis was the protection of the cyanohydrin 7 with enantiomerically pure MBF-lactol, which allows not only easy se