5446-89-9

Usage

Synonyms

6-thioxanthine

Molecular structure

Closely related to caffeine and theobromine

Classification

Purine derivative and xanthine analog

Function

Inhibitor of xanthine oxidase

Enzyme target

Xanthine oxidase, involved in purine metabolism

Applications

a. Study of purine metabolism
b. Research tool for developing xanthine oxidase inhibitors

Potential treatments

Gout and hyperuricemia

Additional investigations

Anti-cancer and anti-inflammatory properties

Relevance

Pharmaceutical research and drug development

Upstream product

• 64-18-6 formic acid 
• 1074-41-5 6-amino-2-methylsulfanylpyrimidin-4(3H)-one 
• 54030-57-8 5,6-diamino-2-(methylthio)pyrimidin-4(3H)-one 
• 122-51-0 orthoformic acid triethyl ester 
• 2487-40-3 2-thioxanthine 
• 77-78-1 dimethyl sulfate 
• 2487-40-3 2,3-dihydro-2-thioxo-9H-purine-6(1H)-one 
• 130890-47-0 5-(N'-Ethoxycarbonylthiocarbamoyl)amino-4-ethoxycarbonylimidazole 
• 54030-57-8 5,6-diamino-4-hydroxy-2-(methylsulfanyl)pyrimidine 
• 64194-62-3 4-amino-5-formamido-6-hydroxy-2-mercaptopyrimidine 
• 2487-40-3 6-hydroxy-2-mercaptopurine 

Downstream Products

• 142581-06-4 2-(4-chloro-anilino)-1,7-dihydro-purin-6-one 
• 19545-00-7 N²-Ethylguanine 
• 1445-15-4 2-(dimethylamino)-1,7-dihydro-6H-purin-6-one 
• 40769-49-1 2-anilino-1,7-dihydro-purin-6-one 
• 10030-78-1 1,7-dihydro-2-(methylamino)-6H-purin-6-one 
• 22529-10-8 2-methylamino-1,7-dihydro-purine-6-thione 
• 66191-23-9 2-methylthio-6-chloropurine 
• 6969-28-4 2-hydrazino-1,7-dihydro-purin-6-one 
• 41286-86-6 2-methanesulfonyl-1,7-dihydro-purin-6-one 
• 66191-23-9 2-methylthio-N-6-chloropurine 
• 1096435-29-8 2-methylthio-6-anilinopurine 
• 1681-11-4 dimethyl-(2-methylsulfanyl-7⁽⁹⁾H-purin-6-yl)-amine 

Relevant academic research and scientific papers

SUBSTITUTED 6-ANILINO-9-HETEROCYCLYLPURINE DERIVATIVES FOR INHIBITION OF PLANT STRESS

The invention relates to substituted 6-anilino-9-heterocyclylpurine derivatives of formula (I) wherein R denotes one to five substituents independently selected from the group comprising hydrogen, halogen, hydroxy, amino, alkyloxy and alkyl group, R2 is s

A novel ionic liquid based on imidazolium cation as an efficient and reusable catalyst for the one-pot synthesis of benzoxazoles, benzthiazoles, benzimidazoles and 2-arylsubstituted benzimidazoles

A novel dicationic ionic liquid based on imidazolium cation is designed, synthesized and successfully used as catalyst for the one-pot synthesis of benzoxazoles, benzthiazoles, benzimidazoles and 2-arylsubstituted benzimidazoles. The remarkable feature of this new catalyst is its ethyleneoxy bridge which participates in dissolving organic compound in ionic liquid. The application of this ionic liquid is studied in a new one-pot method for synthesis of heterocyclic compounds under solvent-free conditions. Simple and convenient procedure, high conversion, reusability of catalyst, easy purification and shorter reaction time are the advantageous features of this method.

Substituted 6-(Benzylamino) Purine Riboside Derivatives, Use Thereof and Compositions Containing These Derivatives

The invention relates to 2-substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I. These compounds possess antiapoptotic, anti-inflammatory and differentiating activities. The invention relates also to the compositions, which contain these derivatives as active ingredients.

SUBSTITUTED 6-(BENZYLAMINO) PURINE RIBOSIDE DERIVATIVES, USE THEREOF AND COMPOSITIONS CONTAINING THESE DERIVATIVES

The invention relates to 2-substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I. These compounds possess antiapoptotic, anti-inflammatory and differentiating activities. The invention relates also to the compositions, which contain these derivatives as active ingredients. ˙

SUBSTITUTED 6-ANILINOPURINE DERIVATIVES AS INHIBITORS OF CYTOKININ OXIDASE/DEHYDROGENASE AND PREPARATIONS CONTAINING THESE DERIVATIVES

The invention relates to substituted 6-anilinopurine derivatives of the general formula I, wherein R denotes one to five substituents independently selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyloxy and alkyl group, and R2 denotes amino, halogen, nitro, thio, alkylthio or alkyl group for use as inhibitors of cytokinin oxidase/dehydrogenase. The invention also relates to the compositions containing these derivatives.

FACILE AND GENERAL SYNTHESIS OF 8-SUBSTITUTED 2-METHYLTHIOPURIN-6-ONES

A variety of 3-methyl-6-oxo-2-thioxo-1,2,3,6-tetrahydropurine (3a) and its 8-substituted derivatives (3b-o) were synthesized by oxidative cyclization of the reaction product of 5,6-diamino-1-methyl-2-thiouracil (1) with an appropriate aldehyde or 6-amino-