1074-85-7

Basic information

• Product Name: INDOLE-4-METHANOL
• Synonyms: RARECHEM AL BD 1201;1H-INDOL-4-YLMETHANOL;4-HYDROXYMETHYLINDOLE;INDOLE-4-METHANOL;4-(Hydroxymethyl)-1H-indole;1H-Indole-4-Methanol
• CAS NO: 1074-85-7
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Product Categories: blocks;IndolesOxindoles;Indole
• Mol File: 1074-85-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 67 °C
• Boiling Point: 360.6°C at 760 mmHg
• Flash Point: 171.9°C
• Appearance: off-white powder.
• Density: 1.272g/cm³
• Vapor Pressure: 7.89E-06mmHg at 25°C
• Refractive Index: 1.705
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 14.56±0.10(Predicted)
• CAS DataBase Reference: INDOLE-4-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: INDOLE-4-METHANOL(1074-85-7)
• EPA Substance Registry System: INDOLE-4-METHANOL(1074-85-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 24/25-36/37/39-39-26
• Hazardous Substances Data: 1074-85-7(Hazardous Substances Data)

Usage

General Description

Indole-4-methanol, also known as 4-Indolemethanol, is a chemical compound with the molecular formula C9H9NO. It is an aromatic compound derived from the natural product indole and is a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and other bioactive compounds. Indole-4-methanol has been studied for its potential antioxidant, antimicrobial, and anti-inflammatory properties, and has shown promising results in various biological and pharmacological studies. It is also a precursor to indole-3-methanol, which is a key compound in the biosynthesis of the plant hormone auxin. Overall, indole-4-methanol has important applications in the fields of medicine, agriculture, and biochemistry, and continues to be of interest to researchers for its potential therapeutic and industrial uses.

InChI:InChI=1/C9H9NO/c11-6-7-2-1-3-9-8(7)4-5-10-9/h1-5,10-11H,6H2

Upstream product

• 39830-66-5 methyl 1H-indole-4-carboxylate 
• 1074-86-8 4-formyl indole 
• 304-59-6 Rochelle's salt 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 75446-71-8 4-aminomethylindole 
• 3468-22-2 (1H-indol-4-yl)-N-methylmethanamine 
• 42792-95-0 2-methyl-5-nitroisoquinolin-2-ium iodide 
• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 77747-70-7 3,4-dihydro-3-methoxy-5-nitroisocoumarin 
• 77747-69-4 5-nitro-1H-isochromen-1-one 
• 81251-05-0 3-hydroxy-5-nitroisochroman 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 75446-77-4 4-aminomethylindole 
• 74068-99-8 (1H-Indol-4-ylmethyl)-dimethyl-amine 

Downstream Products

• 98664-90-5 ethyl (6aRS,9SR,9aSR)-hexahydro-7,7-dimethylisoindolo[4,5,6-cd]indole-9-carboxylate 
• 905274-11-5 indolin-4-ylmethanol 
• 1074-86-8 4-formyl indole 
• 30933-66-5 4-(cyanomethyl)indole 
• 68900-05-0 4-vinylindole 
• 146175-98-6 N-benzyl-4-(2-methoxyvinyl)-3-(3'-trimethylsilylmethyl-2'-hydroxy-but-3'-enyl)indoline 
• 146175-96-4 N-benzyl-3-cyanomethyl-4-(2-methoxyvinyl)indoline 
• 146175-97-5 N-benzyl-3-formylmethyl-4-(2-methoxyvinyl)indoline 

Relevant articles and documents

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4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

The Knight route to cyclopiazonic acid: Enantioselective synthesis of a key intermediate

The indole alkaloid α-cyclopiazonic acid (CPA) is one of the few known inhibitors of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) besides thapsigargin and artemisinin. Inhibitors of SERCA hold promise as novel anticancer and antimalarial drugs. Since its structure elucidation three racemic syntheses of α-cyclopiazonic acid have been published. We report now the first enantioselective and high yielding synthesis of a key-intermediate of the Knight synthesis, currently the most efficient route to CPA. Our synthesis is based on a diastereoselective 1,4-cuprate addition followed by an enolate azidation of an indolylacrylic acid modified with the Evans auxiliary.

Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof

The present invention relates to a method of treating disorders including cognition impairment, generalized anxiety disorder, acute stress disorder, social phobia, simple phobias, pre-menstrual dysphoric disorder, social anxiety disorder, major depressive