107401-27-4

Upstream product

• 5814-06-2 2,4-dichlorobenzohydrazide 
• 123-11-5 4-methoxy-benzaldehyde 
• 56882-52-1 ethyl 2,4-dichlorobenzoate 

Downstream Products

• 128722-53-2 2,4-Dichloro-benzoic acid [1-bromo-1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 130489-70-2 2,4-Dichloro-N-[2-(4-methoxy-phenyl)-4-oxo-thiazolidin-3-yl]-benzamide 
• 128722-46-3 2,4-Dichloro-N-[(2R,3R)-3-chloro-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzamide 
• 128722-39-4 2,4-Dichloro-N-[(2R,3S)-2-(4-methoxy-phenyl)-4-oxo-3-phenyl-azetidin-1-yl]-benzamide 
• 608125-68-4 2,4-dichloro-benzoic acid N'-(4-methoxy-benzyl)-hydrazide 
• 608125-75-3 C₁₆H₁₅Cl₂N₃O₂S 
• 128722-61-2 (3aR,6aR)-1-(2,4-Dichloro-benzoyl)-3-(4-methoxy-phenyl)-3a,6a-dihydro-1H-furo[3,4-c]pyrazole-4,6-dione 
• 128722-69-0 (3aR,6aR)-1-(2,4-Dichloro-benzoyl)-3-(4-methoxy-phenyl)-3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione 
• 128722-77-0 (3aR,6aR)-1-(2,4-Dichloro-benzoyl)-3-(4-methoxy-phenyl)-5-phenyl-3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione 

Relevant academic research and scientific papers

Hit-to-Lead studies: The discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists

A Hit-to-Lead optimisation programme was carried out on the high throughput screening hit, the triazolethiol 1, resulting in the discovery of the potent, orally bioavailable triazolethiol CXCR2 receptor antagonist 45.