107516-75-6

Usage

Uses

Used in Pharmaceutical Research:
6-Ethoxycarbonylindole-2-carboxylic acid ethyl ester is used as a starting material for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups allow for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 6-ethoxycarbonylindole-2-carboxylic acid ethyl ester is used as a building block for the creation of complex organic molecules. Its reactivity and functional groups make it a valuable component in the synthesis of a wide range of organic compounds.
Used in Medicinal Chemistry:
6-Ethoxycarbonylindole-2-carboxylic acid ethyl ester is utilized in medicinal chemistry for the design and development of new drugs. Its potential biological activity and ability to be modified into various derivatives make it a promising candidate for drug discovery.
Used in Drug Discovery:
In the process of drug discovery, 6-ethoxycarbonylindole-2-carboxylic acid ethyl ester is used to explore its potential as a lead compound for the development of new therapeutic agents. Its unique properties and reactivity contribute to the identification of novel drug candidates with potential clinical applications.
Used in Chemical Research:
6-Ethoxycarbonylindole-2-carboxylic acid ethyl ester is employed in chemical research to study its properties, reactivity, and potential applications. This research helps to expand the understanding of its role in various chemical processes and its potential use in the development of new materials and compounds.
Used in Biochemical Studies:
6-Ethoxycarbonylindole-2-carboxylic acid ethyl ester is also used in biochemical studies to investigate its interactions with biological systems. This research can provide insights into its potential use as a therapeutic agent or its role in biological processes.

InChI:InChI=1/C14H15NO4/c1-3-18-13(16)10-6-5-9-7-12(14(17)19-4-2)15-11(9)8-10/h5-8,15H,3-4H2,1-2H3

Upstream product

• 327-21-9 ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate 
• 96315-16-1 4-bromomethyl-3-nitrobenzoic acid ethyl ester 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 19013-15-1 ethyl 4-methyl-3-nitro-benzoate 
• 327-20-8 6-(trifluoromethyl)-1H-indole-2-carboxylic acid 
• 861384-91-0 ethyl 4-(3-ethoxy-2,3-dioxopropyl)-3-nitrobenzoate 
• 103027-97-0 indole-2,6-dicarboxylic acid 

Downstream Products

• 1311366-35-4 N-(3-chlorophenyl)-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311368-46-3 N-(5-benzyl-1,2-oxazol-3-yl)-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311368-49-6 N-(2-carbamoylphenyl)-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311368-60-1 N-[3-(1H-imidazol-4-yl)phenyl]-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311368-63-4 N-[2-(methylcarbamoyl)phenyl]-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311369-80-8 1-oxo-N-[3-(1-trityl-1H-imidazol-4-yl)phenyl]-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311369-58-0 methyl 2-{[(1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indol-8-yl)carbonyl]amino}benzoate 
• 1311369-59-1 2-{[(1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indol-8-yl)carbonyl]amino}benzoic acid 
• 1311369-17-1 diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate 
• 916454-19-8 1-(cyano-methyl-methyl)-1H-indole-2,6-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF INDOLES FROM ACETOACETIC ESTERS

The present invention relates to a synthesizing method of indole using acetoacetic ester and, more specifically, to a synthesizing method of indole which induces reduction of a nitro group into an amine group and aromatic cyclization with a ketone group through hydrogenation using a metal catalyst in a 2-nitrobenzyl ketone compound, after synthesizing the 2-nitrobenzyl ketone compound through deacetylation using a manganese (III) / cobalt (II) catalyst in a 2-nitrobenzyl acetone compound obtained by adding an acetoacetic ester compound in a 2-nitrobenzyl bromide compound.COPYRIGHT KIPO 2016

Tandem catalytic oxidative deacetylation of acetoacetic esters and heteroaromatic cyclizations

One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(iii)/Co(ii) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of ethyl acetoacetate to α,β-unsaturated carbonyl compounds. The oxidative deacetylation and reductive cyclization of β-ketoesters derived from ethyl acetoacetate and o-nitrobenzyl bromides efficiently produced diversely substituted indoles. This journal is

MK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE

Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.

Pyrazinoindolone inhibitors of MAPKAP-K2

Optimization of pyrazinoindolone inhibitors of MAPKAP-K2 (MK2) provides a reasonable balance of cellular potency and physicochemical properties. Mechanistic studies support the inhibition of MK2 which is responsible for the sub-micromolar cellular efficacy.

Anti-Cytokine Heterocyclic Compounds

Heterocyclic compounds and analogues thereof and their use as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.